Evidence map›Paper›PMID 34904201›Full record

ArticlePharmaceutical research2021

Expanding the toolbox for predictive parameters describing antibody stability considering thermodynamic and kinetic determinants.

Michaela Blech, Richard Melien, Nuska Tschammer, Beate Presser, Dariush Hinderberger, Patrick Garidel

Abstract read
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In one paragraph

Article in Pharmaceutical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michaela BlechBoehringer Ingelheim Pharma GmbH & Co. KG, Innovation Unit, Pharmaceutical Development Biologicals, 88397, Biberach an der Riss, Germany. Michaela.Blech@boehringer-ingelheim.com.
Richard MelienBoehringer Ingelheim Pharma GmbH & Co. KG, Innovation Unit, Pharmaceutical Development Biologicals, 88397, Biberach an der Riss, Germany.
Nuska TschammerNanotemper Technologies GmbH, Flößergasse 4, 81369, München, Germany.
Beate PresserAnalytical Development Biologicals, CMC Statistics, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397, Biberach an der Riss, Germany.
Dariush HinderbergerInstitute of Chemistry, Martin-Luther-Universität Halle-Wittenberg, von-Danckelmann-Platz 4, 06120, Halle (Saale), Germany.
Patrick GaridelBoehringer Ingelheim Pharma GmbH & Co. KG, Innovation Unit, Pharmaceutical Development Biologicals, 88397, Biberach an der Riss, Germany.

Funding

German Federal Ministry of Education and Research, funding program KMU-innovativ Photonics Research Germany 13N14245
6 · The paper itself

Abstract

purposeIntroduction of the activation energy (E

methodsE

resultsE

conclusionE

Indexed as

Models, ChemicalAntibodies, MonoclonalChemistry, PharmaceuticalKineticsProtein DenaturationProtein StabilityThermodynamicsAntibodies, Monoclonalactiviation energyantibody stabilityintrinsic fluorescence and differential scanning calorimetrykinetic stabilitypredictive parameterthermal unfoldingthermodynamic stabilityvan’t Hoff enthalpy

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.