ArticleJournal of epidemiology and global health2022
Combined Blood Indexes of Systemic Inflammation as a Mirror to Admission to Intensive Care Unit in COVID-19 Patients: A Multicentric Study.
Article in Journal of epidemiology and global health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systemic inflammation index, disease severity, and mortality in patients with COVID-19: a systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Early systemic inflammatory indices and postoperative SIRS after percutaneous nephrolithotomy under spinal versus general anaesthesia: a prospective cohort study.BMC urology · 2026Observational
- Inflammatory Biomarkers Following Orthopedic Surgery: Current Evidence, Clinical Applications, and Future Perspectives-A Narrative Review.Journal of clinical medicine · 2026Review
- Systemic Inflammatory Indices Predict Survival and Limb Outcomes after Revascularization for Chronic Limb-Threatening Ischemia.Journal of vascular research · 2026Article
- Prognostic value of the aggregate index of systemic inflammation in palliative care patients.Scientific reports · 2026Article
- Association between novel hematological inflammatory indices and prevalent peripheral arterial disease: A cross-sectional analysis from the national health and nutrition examination survey.Science progress · 2026Article
- Prospective Evaluation of Postoperative SIRS and Serum Inflammatory Indices in Percutaneous Nephrolithotomy Patients.Therapeutics and clinical risk management · 2026Article
- The Value of NLR, PLR, MLR, and SII Combined with Lower Respiratory Tract Symptoms in Predicting Pulmonary Complications in Non-Risk-Factor Influenza A Patients.International journal of general medicine · 2026Article
- Association Between the Systemic Inflammatory Response Index and Severe Infection in Patients with Diabetic Foot.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Prognostic Value of Systemic Immune-Inflammation Index (SII) in Hospital Readmission Following Acute Myocardial Infarction: A Four-Year Analysis.Cardiology research and practice · 2026Article
- Serum Albumin Role as a Prognostic Biomarker of Radiological Gonarthrosis Progression: A Retrospective Cross-sectional Study.Indian journal of orthopaedics · 2025Article
- Association Between Peripheral Inflammation Biomarkers and Clinical Phenotypes in Patients With Medication Overuse Headache: A Cross-sectional Study.Brain and behavior · 2025Article
- Observational
- Effects of preoperative inflammation parameters on regional anesthesia blockade times in pregnant women.Pakistan journal of medical sciences · 2025Article
- Predictive value of systemic inflammatory indices for perinatal outcomes following cervical cerclage: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- The aggregate index of systemic inflammation (AISI) and the risk of all-cause, cardiovascular, and cardio-cerebrovascular mortality in congestive heart failure patients: results from NHANES 1999-2018.Scientific reports · 2025Article
- Association between systemic immune-inflammation index and latent tuberculosis infection: a cross-sectional study.Frontiers in medicine · 2025Article
- Article
- Influenza A (H1N1) and COVID-19 Pneumonias: An Evaluation in the Light of New Hematologic Indices.Journal of inflammation research · 2025Article
- Platelets as central hubs of inflammation.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Coronavirus 2019 is a pandemic that has spread worldwide, threatening human health. The main cause of death in patients with COVID-19 is a systemic pro-inflammatory mechanism that quickly progresses to acute respiratory distress syndrome. Hematological ratios as affordable indicators of inflammatory response were studied in COVID-19 patients. The study aimed to study the importance of the blood cell indexes of the systemic inflammatory response, as the Aggregate Index of Systemic Inflammation (AISI), neutrophils lymphocyte to platelet ratio (NLPR), systemic immune-inflammation index (SII) and, systemic inflammation response index (SIRI) in predicting intensive care unit (ICU) admission of COVID-19 patients.
methods495 COVID-19 patients managed in four tertiary centers; divided into non-ICU and ICU groups.
resultsTotal leucocyte count (TLC), AISI, NLPR, SII, and SIRI were more elevated in the ICU group (P < 0.001 for all except AMC P = 0.006), while this group had less absolute lymphocyte count (ALC) (P = 0.047). We estimated the optimal cut-off values of the hematological ratio; AISI (729), NLPR (0.0195), SII (1346), and SIRI (2.5). SII had the highest specificity (95.6%), while NLPR had the highest sensitivity (61.3%). Age, AISI, CRP, D-dimer, and oxygen aid were the independent predictors for ICU admission in COVID-19 in multivariate logistic regression.
conclusionAISI is a predictor for severity and ICU admission in COVID-19 patients, SII is a predictor of survival, while NLPR and SIRI have an additive role that needs further evaluation.
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