Evidence map›Paper›PMID 34904185›Full record

ArticleVirchows Archiv : an international journal of pathology2022

Interobserver agreement of estimating the extent of intestinal metaplasia in patients with chronic atrophic gastritis.

Julia M Lerch, Rish K Pai, Ian Brown, Anthony J Gill, Dhanpat Jain, Bence Kővári, Ryoji Kushima, Kieran Sheahan, Tomas Slavik, Amitabh Srivastava and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Julia M LerchDiagnostic and Research Institute of Pathology, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Neue Stiftingtalstraße 6, 8010, Graz, Austria.
Rish K PaiDepartment of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Ian BrownEnvoi Specialist Pathologists, Brisbane, Queensland, Australia.
Anthony J GillCancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Dhanpat JainDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Bence KőváriDepartment of Pathology, University of Szeged, Szeged, Hungary.
Ryoji KushimaDepartment of Pathology, Shiga University of Medical Science, Shiga, Japan.
Kieran SheahanDepartment of Pathology & Centre for Colorectal Disease, St. Vincent's University Hospital, Dublin, Ireland.
Tomas SlavikAmpath Pathology Laboratories, Pretoria, South Africa.
Amitabh SrivastavaDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Gregory Y LauwersH. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Cord LangnerDiagnostic and Research Institute of Pathology, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Neue Stiftingtalstraße 6, 8010, Graz, Austria. cord.langner@medunigraz.at.ORCID http://orcid.org/0000-0002-0322-8460

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

The extent of gastric intestinal metaplasia (GIM) can be used to determine the risk of gastric cancer. Eleven international gastrointestinal expert pathologists estimated the extent of GIM on haematoxylin and eosin (H&E)- and Alcian blue-Periodic acid Schiff (AB-PAS)-stained slides of 46 antrum biopsies in 5% increments. Interobserver agreement was tested with the intraclass correlation coefficient (ICC). Correlation between standard deviation and extent of GIM was evaluated with the Spearman correlation. The interobserver agreement was very good (ICC = 0.983, 95% confidence interval (CI) 0.975-0.990). The use of AB-PAS did not increase the agreement (ICC = 0.975, 95% CI 0.961-0.985). Cases with a higher amount of metaplastic epithelium demonstrated a higher standard deviation (rs = 0.644; p < 0.01), suggesting lower diagnostic accuracy in cases with extensive GIM. In conclusion, estimating the extent of GIM on H&E-stained slides in patients with chronic atrophic gastritis can be achieved satisfactorily with high interobserver agreement, at least among international expert gastrointestinal pathologists.

Indexed as

Gastritis, AtrophicHelicobacter InfectionsHelicobacter pyloriPrecancerous ConditionsStomach NeoplasmsHumansMetaplasiaObserver VariationChronic atrophic gastritisGastric precancerous lesionInterobserver agreementIntestinal metaplasia

Identifiers

PMID34904185
PMCPMC9184363

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.