Evidence map›Paper›PMID 34904045›Full record

ArticleWorld journal of hepatology2021

Nonalcoholic fatty liver disease is associated with worse intestinal complications in patients hospitalized for

Yi Jiang, Salil Chowdhury, Bing-Hong Xu, Mohamad Aghaie Meybodi, Konstantinos Damiris, Samanthika Devalaraju, Nikolaos Pyrsopoulos

Open access · diamondAbstract read
In one paragraph

Article in World journal of hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Membrane Vesicles of ToxigenicAntioxidants (Basel, Switzerland) · 2023
    Article
  3. World journal of hepatology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yi JiangDepartment of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07101, United States.
Salil ChowdhuryDepartment of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07101, United States.
Bing-Hong XuLiver Center and Center for Asian Health, RWJBH-Saint Barnabas Medical Center, Florham Park, NJ 07932, United States.
Mohamad Aghaie MeybodiDepartment of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07101, United States.
Konstantinos DamirisDepartment of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07101, United States.
Samanthika DevalarajuDepartment of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07101, United States.
Nikolaos PyrsopoulosDepartment of Medicine, Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ 07101, United States. pyrsopni@njms.rutgers.edu.
Rutgers, The State University of New Jersey · USSaint Barnabas Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonalcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease with increasing prevalence worldwide.

aimTo assess the impact of NAFLD on the outcomes of hospitalized patients with CDI.

methodsThis study was a retrospective cohort study. The Nationwide Inpatient Sample database was used to identify a total of 7239 adults admitted as inpatients with a primary diagnosis of CDI and coexisting NAFLD diagnosis from 2010 to 2014 using ICD-9 codes. Patients with CDI and coexisting NAFLD were compared to those with CDI and coexisting alcoholic liver disease (ALD) and viral liver disease (VLD), individually. Primary outcomes included mortality, length of stay, and total hospitalization charges. Secondary outcomes were in-hospital complications. Multivariate regression was used for outcome analysis after adjusting for possible confounders.

resultsCDI with NAFLD was independently associated with lower rates of acute respiratory failure (2.7%

conclusionHospitalized CDI patients with NAFLD had more intestinal complications compared to CDI patients with VLD and ALD. Gut microbiota dysbiosis may contribute to the pathogenesis of intestinal complications.

Indexed as

Alcoholic liver diseaseClostridioides difficile infectionGut microbiotaIntestinal complicationsNonalcoholic fatty liver diseaseViral liver disease

Identifiers

PMID34904045
PMCPMC8637681
OpenAlexW3216965803

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.