Evidence map›Paper›PMID 34904004›Full record

ArticleIranian journal of pharmaceutical research : IJPR2021

Cytotoxicity and Immunogenicity Evaluation of Synthetic Cell-penetrating Peptides for Methotrexate Delivery.

Parvin Zakeri-Milani, Saeedeh Najafi-Hajivar, Muhammad Sarfraz, Ali Nokhodchi, Hamed Mohammadi, Soheila Montazersaheb, Mehri Niazi, Maryam Hemmatzadeh, Mehdi Soleymani-Goloujeh, Behzad Baradaran and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Self-Assembling Short Peptide Carriers for Gene Delivery.International journal of molecular sciences · 2026
    Review
  2. Review
  3. TargetingInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Parvin Zakeri-MilaniLiver and Gastrointestinal Diseases Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Saeedeh Najafi-HajivarStudent Research Committee, and Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Muhammad SarfrazCollege of Pharmacy, Al Ain University, Al Ain 64141, UAE.
Ali NokhodchiPharmaceutics Research Laboratory, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.
Hamed MohammadiImmunology Research Center, and Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Soheila MontazersahebStem Cell Research Center, and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Mehri NiaziStudent Research Committee, and Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Maryam HemmatzadehImmunology Research Center, and Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mehdi Soleymani-GoloujehStudent Research Committee, and Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Behzad BaradaranImmunology Research Center, and Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Javid Shahbazi MojarradBiotechnology Research Center, and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Masoud FarshbafStudent Research Committee, and Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Tooba GholikhaniDrug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Hadi ValizadehDrug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Tabriz University of Medical Sciences · IRAl Ain University · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methotrexate (MTX) is one of the most effective therapeutics to treat different types of solid tumors; however, it suffers low permeability limiting its bioavailability and cellular uptake. To tackle this, we aim to design and fabricate different types of cell-penetrating peptides (CPPs) to improve the intracellular uptake of MTX without causing any immunogenic response. CPPs were synthesized by the solid-phase peptide synthesis method. Peptide-MTX conjugates were prepared

Indexed as

CancerCPPsDrug deliveryImmune systemNanoparticles

Identifiers

PMID34904004
PMCPMC8653662
OpenAlexW3209011207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.