Evidence map›Paper›PMID 34904001›Full record

ArticleIranian journal of pharmaceutical research : IJPR2021

Synthesis and Decarboxylation of Functionalized 2-Pyridone-3-carboxylic Acids and Evaluation of their Antimicrobial Activity and Molecular Docking.

Elmira Meghrazi Ahadi, Homa Azizian, Vaezeh Fathi Vavsari, Atousa Aliahmadi, Zeinab Shahsavari, Hamid R Bijanzadeh, Saeed Balalaie

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Elmira Meghrazi AhadiPeptide Chemistry Research Institute, K. N. Toosi University of Technology, Tehran, Iran.
Homa AzizianDepartment of Medicinal Chemistry, School of Pharmacy, International Campus, Iran University of Medical Sciences, Tehran, Iran.
Vaezeh Fathi VavsariPeptide Chemistry Research Institute, K. N. Toosi University of Technology, Tehran, Iran.
Atousa AliahmadiMedicinal Plant and Drug Research Institute, Shahid Beheshti University, Tehran, Iran.
Zeinab ShahsavariMedicinal Plant and Drug Research Institute, Shahid Beheshti University, Tehran, Iran.
Hamid R BijanzadehDepartment of Environmental Sciences, Faculty of Natural Resources and Marine Sciences, Tarbiat Modares University, Tehran, Iran.
Saeed BalalaiePeptide Chemistry Research Institute, K. N. Toosi University of Technology, Tehran, Iran.
K.N.Toosi University of Technology · IRShahid Beheshti University · IRIran University of Medical Sciences · IRTarbiat Modares University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The functionalized 2-pyridone-3-carboxylic acids were synthesized starting from 3-formylchromone. Meanwhile, a decarboxylation reaction of 2-pyridone-3-carboxylic acid was performed by potassium carbonate in toluene. All compounds were evaluated against two Gram-negative bacteria (

Indexed as

2-PyridoneADME propertiesDecarboxylation reactionInduced fit dockingMolecular dynamicMulticomponent reactions; Antibiotics

Identifiers

PMID34904001
PMCPMC8653659
OpenAlexW3209910089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.