ArticleNature metabolism2021
NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding.
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Article in Nature metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
59 citing papers in PubMed, 66 citations in OpenAlex.
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- Metabolic Flux Adaptations During GLP-1 Receptor Agonist Therapy: Redox Implications.Current obesity reports · 2026Review
- Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome.Nature metabolism · 2026Article
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- Progress of Research on the Metabolic Regulation of Lactylation in Muscle Tissues and Its Disease Associations.Biomolecules · 2026Review
- The Role of Histone Modifications in Acute Lung Injury: Molecular Mechanisms and Potential of Traditional Chinese Medicine Treatment.Journal of inflammation research · 2026Review
- Nutritional adaptation to circadian misalignment: implications for musculoskeletal health in modern lifestyles.Frontiers in nutrition · 2026Review
- Circadian clock and cancer.Military Medical Research · 2026Review
- Keeping up with the nicotinamides: NADP(H), the forgotten circadian cofactor that keeps metabolic time.Life metabolism · 2025Review
- The Role of Hepatic SIRT1: From Metabolic Regulation to Immune Modulation and Multi-target Therapeutic Strategies.Journal of clinical and translational hepatology · 2025Review
- Unsaturated fat alters clock phosphorylation to align rhythms to the season in mice.Science (New York, N.Y.) · 2025Article
- Comparative Analysis of the Tolerance of Young and Old Kidneys to Injury in a Rat Model of Reversible Ureteral Obstruction.Antioxidants (Basel, Switzerland) · 2025Article
- The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans.Journal of biomedical science · 2025Review
- Beneficial effect of resveratrol on T cell oxidative metabolism and anti-tumor function is conditioned by priorMolecular therapy. Methods & clinical development · 2025Article
- Circadian Rhythm Cascade SIRT1/PGC-1α/BMAL1 Pathway Regulates Nitroglycerin-Induced Chronic Migraine.Neurochemical research · 2025Article
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Authors and funding
19 authors at 2 institutions in 3 countries.
Daniel C LevineDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-3453-951X
Hsin-Yu KuoDepartments of Chemistry, Biomedical Engineering, and Cell and Molecular Biology, Northwestern University, Evanston, IL, USA.
Hee-Kyung HongDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Jonathan CedernaesDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9052-8372
Chelsea HeplerDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9938-382X
Alexandra G WrightDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-1981-0180
Meredith A SommarsDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Yumiko KobayashiDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Biliana MarchevaDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Peng GaoRobert H. Lurie Cancer Center Metabolomics Core, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9991-6064
Olga R IlkayevaDuke Molecular Physiology Institute, Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-9779-0883
Chiaki OmuraDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4810-4290
Kathryn M RamseyDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-0691-7835
Christopher B NewgardDuke Molecular Physiology Institute, Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-1293-691X
Grant D BarishDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8753-0546
Clara Bien PeekDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Navdeep S ChandelDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-7208-3886
Milan MrksichDepartments of Chemistry, Biomedical Engineering, and Cell and Molecular Biology, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-4964-796X
Joseph BassDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. j-bass@northwestern.edu.ORCID http://orcid.org/0000-0002-1602-8601
Northwestern University · USDuke University · US
Funding
SLOW WAVE SLEEP AND TYPE 2 DIABETES RISK IN AGINGP01AG011412 · NIA · UNIVERSITY OF CHICAGO · PI TUREK, FRED W · 1994 to 2021
$31.5MTissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9MCELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1MProject 3: Spherical Nucleic Acids as Immunotherapeutic Agents for Prostate CancerU54CA199091 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MIRKIN, CHAD A. · 2015 to 2019
$11.7MPilot & Feasibility ProgramP30DK124723 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI P Darrell Neufer · 2020 to 2026
$11.0MTRAINING GRANT IN SLEEP RESEARCHT32HL007909 · NHLBI · NORTHWESTERN UNIVERSITY · PI FRED W TUREK, Phyllis C. Zee · 1998 to 2026
$9.2MIntegration of Feeding Time and Glucose Metabolism by the Circadian Gene NetworkR01DK090625 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH, LERNER, TALIA NEWCOMBE · 2011 to 2025
$6.9MPDX-1,A TRANSCRIPTIONAL ACTIVATOR OF THE INSULIN GENER01DK050203 · NIDDK · VANDERBILT UNIVERSITY · PI BASS, JOSEPH, STEIN, ROLAND W · 1995 to 2020
$6.8MMitochondrial metabolism and ROS regulate cancerR35CA197532 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2016 to 2022
$6.3MNuclear Repressors in Genomic Control of Healthful ObesityR01DK108987 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BARISH, GRANT D · 2016 to 2024
$3.4MIntegrative Genomics, Epigenomics and Bioinformatics Analyses of Human Uterine FibroidsR01HD089552 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BARISH, GRANT D, BULUN, SERDAR E. · 2016 to 2020
$3.4MCross-regulation of Immunometabolism and Circadian Pathways in Obesity PathophysiologyR01DK127800 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2021 to 2025
$2.3MNCI NIH HHS R35 CA197532NCI NIH HHS U54 CA199091NHLBI NIH HHS T32 HL007909NIA NIH HHS P01 AG011412NIA NIH HHS P01 AG049665NIA NIH HHS R01 AG065988NICHD NIH HHS R01 HD089552NIDDK NIH HHS F32 DK122675NIDDK NIH HHS K01 DK105137NIDDK NIH HHS P30 DK124723NIDDK NIH HHS R01 DK050203NIDDK NIH HHS R01 DK090625NIDDK NIH HHS R01 DK100814NIDDK NIH HHS R01 DK108987NIDDK NIH HHS R01 DK113011NIDDK NIH HHS R01 DK127800NIDDK NIH HHS R03 DK116012NIGMS NIH HHS T32 GM008061
Abstract
In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD
Indexed as
Energy MetabolismFastingTranscription, GeneticAmino AcidsAnimalsBody TemperatureCircadian RhythmDietFatty AcidsGene Expression RegulationLiverMiceNADSirtuin 1Transcription FactorsAmino AcidsFatty AcidsNADSirtuin 1Transcription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.