Evidence map›Paper›PMID 34903859›Full record

ArticleNature chemistry2022

Arene radiofluorination enabled by photoredox-mediated halide interconversion.

Wei Chen, Hui Wang, Nicholas E S Tay, Vincent A Pistritto, Kang-Po Li, Tao Zhang, Zhanhong Wu, David A Nicewicz, Zibo Li

Abstract read
In one paragraph

Article in Nature chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Chemical science · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Visible-Light SThe Journal of organic chemistry · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. EDA photochemistry using continuous flow.Journal of flow chemistry · 2025
    Review
  13. Article
  14. One-Step Synthesis of [ACS central science · 2024
    Article
  15. Manufacturing 6-[Organic letters · 2024
    Article
  16. Review
  17. Synthetic Advantages of Defluorinative C-F Bond Functionalization.Angewandte Chemie (International ed. in English) · 2023
    Review
  18. Review
  19. Development of [Journal of medicinal chemistry · 2023
    Article
  20. Chem · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei ChenBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-3694-5204
Hui WangBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nicholas E S TayDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Vincent A PistrittoDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-6897-8799
Kang-Po LiBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tao ZhangBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-0920-0151
Zhanhong WuBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
David A NicewiczDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. nicewicz@unc.edu.ORCID http://orcid.org/0000-0003-1199-9879
Zibo LiBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ziboli@med.unc.edu.ORCID http://orcid.org/0000-0002-1063-0298

Funding

Novel Catalytic Methods for Efficient Radiolabeling of Un-activated Arene Compounds SupplementR01EB029451 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO, NICEWICZ, DAVID A · 2020 to 2023
$2.2M
Development of IDO PET agents for immunotherapyR01CA233904 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO, MOSCHOS, STERGIOS · 2019 to 2023
$2.0M
Exceptional Aging Across the Life Span: Framingham StudyR01AG029451 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MURABITO, JOANNE M · 2008 to 2011
$1.3M
Small Animal PET/CT for Preclinical Imaging ResearchS10OD023611 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO · 2017 to 2017
$835k
Novel multi-omics approach to the biology of healthy aging: Framingham StudyR56AG029451 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LUNETTA, KATHRYN L, MURABITO, JOANNE M · 2015 to 2015
$474k
NCI NIH HHS R01 CA233904NIBIB NIH HHS R01 EB029451NIH HHS S10 OD023611
6 · The paper itself

Abstract

Positron emission tomography (PET) is a powerful imaging technology that can visualize and measure metabolic processes in vivo and/or obtain unique information about drug candidates. The identification of new and improved molecular probes plays a critical role in PET, but its progress is somewhat limited due to the lack of efficient and simple labelling methods to modify biologically active small molecules and/or drugs. Current methods to radiofluorinate unactivated arenes are still relatively limited, especially in a simple and site-selective way. Here we disclose a method for constructing C-

Indexed as

Photochemical ProcessesFluorine RadioisotopesHalogensOxidation-ReductionPositron-Emission TomographyFluorine RadioisotopesHalogens

Identifiers

PMID34903859
PMCPMC9617144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.