ArticleThe ISME journal2022
Mammalian gut metabolomes mirror microbiome composition and host phylogeny.
Article in The ISME journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Animal gut microbes and microbiomes in the 21st century and beyond.Science China. Life sciences · 2026Review
- Metabolic strategies of Enterobacteriaceae gut colonization.Nature reviews. Microbiology · 2026Review
- Joint-RPCA: domain-aware multi-omics integration for systems microbiology.Molecular systems biology · 2026Article
- Comparative Analysis of Gastrointestinal Microbiota Along the Digestive Tract in Sika Deer and Reindeer and Prediction of Their Potential Function.Animals : an open access journal from MDPI · 2026Article
- Deciphering potential significances of biliary microbiome in cholelithiasis and cholangiocarcinoma.Antonie van Leeuwenhoek · 2026Article
- Tick-vectored mobilization of antibiotic resistance genes: transboundary dissemination across wildlife-livestock-vector-environment interfaces.NPJ biofilms and microbiomes · 2026Article
- Association between castration-induced changes in circadian body temperature rhythms and gut microbiome diversity in goats.Scientific reports · 2026Article
- MS/MS Mass Spectrometry Filtering Tree for Bile Acid Regio- and Stereoisomer Annotation.Analytical chemistry · 2026Article
- Navigating the conjugated metabolome.bioRxiv : the preprint server for biology · 2026Article
- Pseudoalteromonas is a symbiont of marine invertebrates that exhibits broad patterns of phylosymbiosis.The ISME journal · 2026Article
- Disrupted terminal bilirubin catabolism linksFrontiers in microbiology · 2026Article
- Rumen Fluid Metabolomics and Microbiome Profiling of Dairy Cows Fed Combinations of Prebiotics, Essential Oil Blend, and Onion Peel Using the RUSITEC System.Metabolites · 2025Article
- Comparison of Gut Microbial Structure and Function Changes in Sichuan-Tibetan Black Pigs at Different Growth Stages Based on Metagenomic Analysis.Current issues in molecular biology · 2025Article
- Article
- Symphony of Digestion: Coordinated Host-Microbiome Enzymatic Interplay in Gut Ecosystem.Biomolecules · 2025Review
- MS/MS Mass Spectrometry Filtering Tree for Bile Acid Isomer Annotation.bioRxiv : the preprint server for biology · 2025Article
- The Faecal Microbiome Analysed from Healthy, Free-Roaming Giraffes (Giraffa camelopardalis).Current microbiology · 2025Article
- Article
- Trait-based study predicts glycerol/diol dehydratases as a key function of the gut microbiota of hindgut-fermenting carnivores.Microbiome · 2024Article
- Comparative analysis of the gut microbiome of ungulate species from Qinghai-Xizang plateau.Ecology and evolution · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
In the past decade, studies on the mammalian gut microbiome have revealed that different animal species have distinct gut microbial compositions. The functional ramifications of this variation in microbial composition remain unclear: do these taxonomic differences indicate microbial adaptations to host-specific functionality, or are these diverse microbial communities essentially functionally redundant, as has been indicated by previous metagenomics studies? Here, we examine the metabolic content of mammalian gut microbiomes as a direct window into ecosystem function, using an untargeted metabolomics platform to analyze 101 fecal samples from a range of 25 exotic mammalian species in collaboration with a zoological center. We find that mammalian metabolomes are chemically diverse and strongly linked to microbiome composition, and that metabolome composition is further correlated to the phylogeny of the mammalian host. Specific metabolites enriched in different animal species included modified and degraded host and dietary compounds such as bile acids and triterpenoids, as well as fermentation products such as lactate and short-chain fatty acids. Our results suggest that differences in microbial taxonomic composition are indeed translated to host-specific metabolism, indicating that taxonomically distant microbiomes are more functionally diverse than redundant.
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