ArticleScientific reports2021
Metabolic profiling reveals nutrient preferences during carbon utilization in Bacillus species.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Genome-based predictions of metabolic preferences and substrate phenotypes in psychrotrophic bacteria from permafrost environments.Microbiology spectrum · 2026Article
- Article
- A ProbioticMicroorganisms · 2026Article
- Effect of carbohydrate substrates on growth and enterotoxin gene expression in Bacillus cereus (pacificus).Scientific reports · 2025Article
- Root-exuded sugars as drivers of rhizosphere microbiome assembly.Plant biotechnology (Tokyo, Japan) · 2025Article
- Fast-growingbioRxiv : the preprint server for biology · 2025Article
- Enhanced recovery of rare earth elements from carbonatite ore by biological pretreatment.RSC advances · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
The genus Bacillus includes species with diverse natural histories, including free-living nonpathogenic heterotrophs such as B. subtilis and host-dependent pathogens such as B. anthracis (the etiological agent of the disease anthrax) and B. cereus, a cause of food poisoning. Although highly similar genotypically, the ecological niches of these three species are mutually exclusive, which raises the untested hypothesis that their metabolism has speciated along a nutritional tract. Here, we developed a pipeline for quantitative total assessment of the use of diverse sources of carbon for general metabolism to better appreciate the "culinary preferences" of three distinct Bacillus species, as well as related Staphylococcus aureus. We show that each species has widely varying metabolic ability to utilize diverse sources of carbon that correlated to their ecological niches. This approach was applied to the growth and survival of B. anthracis in a blood-like environment and find metabolism shifts from sugar to amino acids as the preferred source of energy. Finally, various nutrients in broth and host-like environments are identified that may promote or interfere with bacterial metabolism during infection.
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