ArticleScientific reports2021
Increased resting state connectivity in the anterior default mode network of idiopathic epileptic dogs.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Investigating gray matter volumes in idiopathic epileptic Border Collies and Greater Swiss Mountain Dogs using voxel-based morphometry.Frontiers in veterinary science · 2026Article
- The Comparison of Functional Connectivity in Parkinson's Disease Patients with and without Parkin Gene Mutations.Noro psikiyatri arsivi · 2025Article
- Efficacy Assessment of Cerebral Perfusion Augmentation through Functional Connectivity in an Acute Canine Stroke Model.AJNR. American journal of neuroradiology · 2024Article
- Flow augmentation therapies preserve brain network integrity and hemodynamics in a canine permanent occlusion model.Scientific reports · 2024Article
- Magnetic resonance imaging in canine idiopathic epilepsy: a mini-review.Frontiers in veterinary science · 2024Review
- Diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogs.Frontiers in veterinary science · 2024Review
- Central nodes of canine functional brain networks are concentrated in the cingulate gyrus.Brain structure & function · 2023Article
- Diffusion tensor-based analysis of white matter in dogs with idiopathic epilepsy.Frontiers in veterinary science · 2023Article
- Ketamine administration in idiopathic epileptic and healthy control dogs: Can we detect differences in brain metabolite response with spectroscopy?Frontiers in veterinary science · 2022Article
- Single-Voxel Proton Magnetic Resonance Spectroscopy of the Thalamus in Idiopathic Epileptic Dogs and in Healthy Control Dogs.Frontiers in veterinary science · 2022Article
- Correlation between semiautomated magnetic resonance imaging volumetry of the cingulate gyrus and interictal epileptiform discharge lateralization in dogs with idiopathic epilepsy.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is one of the most common chronic, neurological diseases in humans and dogs and considered to be a network disease. In human epilepsy altered functional connectivity in different large-scale networks have been identified with functional resting state magnetic resonance imaging. Since large-scale resting state networks have been consistently identified in anesthetised dogs' application of this technique became promising in canine epilepsy research. The aim of the present study was to investigate differences in large-scale resting state networks in epileptic dogs compared to healthy controls. Our hypothesis was, that large-scale networks differ between epileptic dogs and healthy control dogs. A group of 17 dogs (Border Collies and Greater Swiss Mountain Dogs) with idiopathic epilepsy was compared to 20 healthy control dogs under a standardized sevoflurane anaesthesia protocol. Group level independent component analysis with dimensionality of 20 components, dual regression and two-sample t test were performed and revealed significantly increased functional connectivity in the anterior default mode network of idiopathic epileptic dogs compared to healthy control dogs (p = 0.00060). This group level differences between epileptic dogs and healthy control dogs identified using a rather simple data driven approach could serve as a starting point for more advanced resting state network analysis in epileptic dogs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.