ArticleTranslational psychiatry2021
The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
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Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.Translational psychiatry · 2025Pooled it
- An Ultrathin, Permeable, and Battery-Free Monolithically Integrated System for Emotion Sensing and Interaction.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Exploring Body Roundness Index's Mediating Role in the Depression-Cognitive Performance Relationship Among US Adults (≥60 Years): Evidence From National Health and Nutrition Examination Survey.Psychiatry investigation · 2026Article
- The association between age at menopause and circadian syndrome: a study based on the UK Biobank.BMC public health · 2026Article
- Testing bidirectional associations of major depressive disorder with medical conditions: two-sample Mendelian randomization study.Npj mental health research · 2026Article
- The Association Between Depression and Idiopathic Pulmonary Fibrosis: A Prospective Study in the UK Biobank.Journal of epidemiology and global health · 2026Article
- Association Between Metabolic Syndrome and Psychiatric Morbidity in a Nationwide Taiwanese Population Study.Nutrients · 2026Article
- L-shaped association between fasting blood glucose and comorbid anxiety in Chinese patients with first-episode untreated major depressive disorder.World journal of psychiatry · 2026Article
- Associations Between Depression Severity, Antidepressant Use, and Metabolic Syndrome Components Among Chinese Adults: A Cross-Sectional Study Based on Historical Medical Records.Actas espanolas de psiquiatria · 2026Article
- Trends in Depression and Its Association With Gallstones: Evidence From NHANES With Exploration of Mediating Pathways.Depression and anxiety · 2026Article
- A proposed psychometabolic endotype of polyendocrine metabolic ovarian syndrome: bidirectional interplay between psychological distress, eating dysfunction, sleep disruption, chronic stress, and metabolic deterioration.Frontiers in endocrinology · 2026Review
- Integrated metabolomics reveals lipid mediators and food-associated chemicals associated with metabolic syndrome.Frontiers in nutrition · 2026Article
- Impact of a combined care ambulatory and home-based aerobic exercise program using wearables on anxiety and depression in patients with metabolic syndrome.Frontiers in cardiovascular medicine · 2026Article
- Metabolic risk stratification and psychotic symptoms in first-episode drug-naïve major depressive disorder: a principal component-based cross-sectional study.Frontiers in psychiatry · 2026Article
- Joint Association of Depression and Sleep Duration With All-Cause and Cardiovascular Mortality: A Cross-Sectional Study With Inflammation Mediation Analysis.Health science reports · 2025Article
- Bidirectional genetic overlap between psychiatric disorders and high-density lipoprotein cholesterol levels.Lipids in health and disease · 2025Article
- Mood and Metabolism: A Bayesian Network Analysis of Depressive Symptoms in Major Depressive Disorder and Metabolic Syndrome.Journal of personalized medicine · 2025Article
- Stress-related multisystem dysregulation during adolescence predicts mental health symptoms in young adulthood.Psychological medicine · 2025Article
- Genetic susceptibility to depression and risk of cardiometabolic diseases: a systematic review and meta-analysis of 21 Mendelian randomisation studies.EClinicalMedicine · 2025Article
- Evidence of bidirectional relationship between type 2 diabetes and depression; a Mendelian randomization study.Molecular psychiatry · 2025Article
30 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
Observational studies suggested a bidirectional correlation between depression and metabolic syndrome (MetS) and its components. However, the causal associations between them remained unclear. We aimed to investigate whether genetically predicted depression is related to the risk of MetS and its components, and vice versa. We performed a bidirectional two-sample Mendelian randomization (MR) study using summary-level data from the most comprehensive genome-wide association studies (GWAS) of depression (n = 2,113,907), MetS (n = 291,107), waist circumference (n = 462,166), hypertension (n = 463,010) fasting blood glucose (FBG, n = 281,416), triglycerides (n = 441,016), high-density lipoprotein cholesterol (HDL-C, n = 403,943). The random-effects inverse-variance weighted (IVW) method was applied as the primary method. The results identified that genetically predicted depression was significantly positive associated with risk of MetS (OR: 1.224, 95% CI: 1.091-1.374, p = 5.58 × 10
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