Evidence map›Paper›PMID 34903726›Full record

ArticleTranslational psychiatry2021

Regional gray matter oligodendrocyte- and myelin-related measures are associated with differential susceptibility to stress-induced behavior in rats and humans.

Kimberly L P Long, Linda L Chao, Yurika Kazama, Anjile An, Kelsey Y Hu, Lior Peretz, Dyana C Y Muller, Vivian D Roan, Rhea Misra, Claire E Toth and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Methylone promotes neurite outgrowth and has long-lasting effects on fear extinction learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 2 countries.

Kimberly L P LongHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.ORCID 0000-0002-4579-8912
Linda L ChaoDepartment of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.
Yurika KazamaHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.
Anjile AnHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.
Kelsey Y HuHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.
Lior PeretzDepartment of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Dyana C Y MullerDepartment of Computer Science, University of Arizona, Tucson, AZ, 85721, USA.
Vivian D RoanHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.
Rhea MisraHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.
Claire E TothHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.ORCID 0000-0003-1811-4180
Jocelyn M BretonHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.ORCID 0000-0003-0981-1451
William CasazzaDepartment of Statistics and Department of Medical Genetics, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.ORCID 0000-0002-4636-4710
Sara MostafaviDepartment of Statistics and Department of Medical Genetics, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
Bertrand R HuberDepartment of Neurology, Boston University, Boston, MA, 02215, USA.
Steven H WoodwardNational Center for PTSD, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
Thomas C NeylanDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, 94143, USA.ORCID 0000-0002-1572-2626
Daniela KauferHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA. danielak@berkeley.edu.ORCID 0000-0002-3830-5999
University of California, Berkeley · USUniversity of California, San Francisco · USCanadian Institute for Advanced Research · CABoston University · USColumbia University · USCornell University · USUniversity of Arizona · USUniversity of British Columbia · CAUniversity of California, Los Angeles · USVA Palo Alto Health Care System · US

Funding

Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSPR01AG060477 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Lea Tenenholz Grinberg, Thomas C Neylan · 2019 to 2026
$8.2M
Individual Variation in Effects of Traumatic Stress on Gray Matter MyelinR01MH115020 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI KAUFER, DANIELA, NEYLAN, THOMAS C · 2019 to 2023
$3.9M
NIA NIH HHS R01 AG060477NIMH NIH HHS R01 MH115020U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH115020
6 · The paper itself

Abstract

Individual reactions to traumatic stress vary dramatically, yet the biological basis of this variation remains poorly understood. Recent studies demonstrate the surprising plasticity of oligodendrocytes and myelin with stress and experience, providing a potential mechanism by which trauma induces aberrant structural and functional changes in the adult brain. In this study, we utilized a translational approach to test the hypothesis that gray matter oligodendrocytes contribute to traumatic-stress-induced behavioral variation in both rats and humans. We exposed adult, male rats to a single, severe stressor and used a multimodal approach to characterize avoidance, startle, and fear-learning behavior, as well as oligodendrocyte and myelin basic protein (MBP) content in multiple brain areas. We found that oligodendrocyte cell density and MBP were correlated with behavioral outcomes in a region-specific manner. Specifically, stress-induced avoidance positively correlated with hippocampal dentate gyrus oligodendrocytes and MBP. Viral overexpression of the oligodendrogenic factor Olig1 in the dentate gyrus was sufficient to induce an anxiety-like behavioral phenotype. In contrast, contextual fear learning positively correlated with MBP in the amygdala and spatial-processing regions of the hippocampus. In a group of trauma-exposed US veterans, T1-/T2-weighted magnetic resonance imaging estimates of hippocampal and amygdala myelin associated with symptom profiles in a region-specific manner that mirrored the findings in rats. These results demonstrate a species-independent relationship between region-specific, gray matter oligodendrocytes and differential behavioral phenotypes following traumatic stress exposure. This study suggests a novel mechanism for brain plasticity that underlies individual variance in sensitivity to traumatic stress.

Indexed as

Gray MatterMyelin SheathAmygdalaAnimalsHippocampusHumansMaleMyelin Basic ProteinOligodendrogliaRatsMyelin Basic Protein

Identifiers

PMID34903726
PMCPMC8668977
OpenAlexW4200373216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.