Evidence map›Paper›PMID 34903713›Full record

ArticleNature communications2021

Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions.

Sandhya Chandrasekaran, Sergio Espeso-Gil, Yong-Hwee Eddie Loh, Behnam Javidfar, Bibi Kassim, Yueyan Zhu, Yuan Zhang, Yuhao Dong, Lucy K Bicks, Haixin Li and 10 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Epigenetics and the timing of neuronal differentiation.Current opinion in neurobiology · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. The Molecular Impacts of Retrotransposons in Development and Diseases.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Sandhya ChandrasekaranDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0003-1730-293X
Sergio Espeso-GilDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0001-9145-3870
Yong-Hwee Eddie LohNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Behnam JavidfarDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Bibi KassimDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Yueyan ZhuState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, 200032, Shanghai, China.
Yuan ZhangState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, 200032, Shanghai, China.
Yuhao DongState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, 200032, Shanghai, China.
Lucy K BicksDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Haixin LiDepartment of Genetics, Yale School of Medicine, New Haven, CT, 06520, USA.
Prashanth RajarajanDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Cyril J PeterDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0001-9190-8724
Daijing SunState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, 200032, Shanghai, China.
Esperanza Agullo-PascualNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marina IskhakovaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Molly EstillNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bluma J LeschDepartment of Genetics, Yale School of Medicine, New Haven, CT, 06520, USA.ORCID http://orcid.org/0000-0002-6689-0240
Li ShenNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-5190-2851
Yan JiangState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, 200032, Shanghai, China. yan_jiang@fudan.edu.cn.ORCID http://orcid.org/0000-0002-5002-4284
Schahram AkbarianDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. schahram.akbarian@mssm.edu.ORCID http://orcid.org/0000-0001-7700-0891
Icahn School of Medicine at Mount Sinai · USFudan University · CNTongji University · CNUniversity of Southern California · USYale Cancer Center · US

Funding

REPRESSIVE HISTONE AND DNA METHYLATION IN RODENT DEPRESSION MODELSP50MH096890 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALLIS, CHARLES DAVID · 2012 to 2021
$20.2M
Higher Order Chromatin and Genetic Risk for SchizophreniaR01MH106056 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, BRENNAND, KRISTEN JENNIFER · 2015 to 2023
$6.7M
Research Training in the Neuroscience of AgingT32AG049688 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Joseph Michael Castellano, PATRICK R HOF · 2015 to 2026
$3.0M
Epigenomic Regulation of a Large, Neuron-specific Chromatin DomainR01MH117790 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM · 2018 to 2022
$2.1M
NIA NIH HHS T32 AG049688NIMH NIH HHS P50 MH096890NIMH NIH HHS R01 MH106056NIMH NIH HHS R01 MH117790
6 · The paper itself

Abstract

Regulatory mechanisms associated with repeat-rich sequences and chromosomal conformations in mature neurons remain unexplored. Here, we map cell-type specific chromatin domain organization in adult mouse cerebral cortex and report strong enrichment of Endogenous Retrovirus 2 (ERV2) repeat sequences in the neuron-specific heterochromatic B

Indexed as

AnimalsCerebral CortexChromosomesDNA-Binding ProteinsEndogenous RetrovirusesEvolution, MolecularGene AmplificationGene SilencingGenes, Intracisternal A-ParticleGenome, ViralGliosisHistone-Lysine N-MethyltransferaseMiceMicrogliaNerve Tissue ProteinsNeuronsDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseNerve Tissue ProteinsNeuN protein, mouseRetroelementsSETDB1 protein, mouse

Identifiers

PMID34903713
PMCPMC8669064
OpenAlexW4225345701

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.