ArticleProceedings of the National Academy of Sciences of the United States of America2021
Multiplexed sensing of biomolecules with optically detected magnetic resonance of nitrogen-vacancy centers in diamond.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 29 citations in OpenAlex.
- Quantum-enhanced diamond molecular tension microscopy for quantifying cellular forces.Science advances · 2024Article
- Digital Magnetic Detection of Biomolecular Interactions with Single Nanoparticles.Nano letters · 2023Article
- Diamond surface engineering for molecular sensing with nitrogen-vacancy centers.Journal of materials chemistry. C · 2022Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the past decade, a great effort has been devoted to develop new biosensor platforms for the detection of a wide range of analytes. Among the various approaches, magneto-DNA assay platforms have received extended interest for high sensitive and specific detection of targets with a simultaneous manipulation capacity. Here, using nitrogen-vacancy quantum centers in diamond as transducers for magnetic nanotags (MNTs), a hydrogel-based, multiplexed magneto-DNA assay is presented. Near-background-free sensing with diamond-based imaging combined with noninvasive control of chemically robust nanotags renders it a promising platform for applications in medical diagnostics, life science, and pharmaceutical drug research. To demonstrate its potential for practical applications, we employed the sensor platform in the sandwich DNA hybridization process and achieved a limit of detection in the attomolar range with single-base mismatch differentiation.
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Registered trials
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