ArticleProceedings of the National Academy of Sciences of the United States of America2021
Competitive dynamics underlie cognitive improvements during sleep.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- Article
- Effects of sleep quality on the offline storage state of visual working memory.BMC psychology · 2026Article
- Bifurcations and Hyperchaos in Mathematical Models of Sleep.Bioengineering (Basel, Switzerland) · 2026Review
- Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.bioRxiv : the preprint server for biology · 2026Article
- Altered rhythmic and arrhythmic electroencephalographic activity during non-rapid eye movement sleep in amnestic mild cognitive impairment.Brain communications · 2026Article
- A user's introduction to an algorithmic method to identify space-time profiles of sleep slow oscillations: dataset constraints, case-use examples, and open-source code.Sleep advances : a journal of the Sleep Research Society · 2026Article
- REM refines and rescues memory representations: a new theory.Sleep advances : a journal of the Sleep Research Society · 2025Review
- Vagal heart rate variability during rapid eye movement sleep reduces negative memory bias.Frontiers in behavioral neuroscience · 2025Article
- Age-associated sleep spindle characteristics in Duchenne muscular dystrophy.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Annual changes ofiScience · 2023Article
- Correlation of Various Sleep Patterns on Different Types of Memory Retention: A Systematic Review.Cureus · 2023Review
- Sleep slow waves' negative-to-positive-phase transition: a marker of cognitive and apneic status in aging.Sleep · 2023Article
- Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Effects of Multisession Prefrontal Transcranial Direct Current Stimulation on Long-term Memory and Working Memory in Older Adults.Journal of cognitive neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We provide evidence that human sleep is a competitive arena in which cognitive domains vie for limited resources. Using pharmacology and effective connectivity analysis, we demonstrate that long-term memory and working memory are served by distinct offline neural mechanisms that are mutually antagonistic. Specifically, we administered zolpidem to increase central sigma activity and demonstrated targeted suppression of autonomic vagal activity. With effective connectivity, we determined the central activity has greater causal influence over autonomic activity, and the magnitude of this influence during sleep produced a behavioral trade-off between offline long-term and working memory processing. These findings suggest a sleep switch mechanism that toggles between central sigma-dependent long-term memory and autonomic vagal-dependent working memory processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.