Evidence map›Paper›PMID 34903561›Full record

ArticleLife science alliance2022

Fms-like tyrosine kinase 3 is a regulator of the cardiac side population in mice.

Giacomo Della Verde, Michika Mochizuki, Vera Lorenz, Julien Roux, Lifen Xu, Leandra Ramin-Wright, Otmar Pfister, Gabriela M Kuster

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Giacomo Della VerdeDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID 0000-0001-8357-9705
Michika MochizukiDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Vera LorenzDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Julien RouxDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID 0000-0002-4192-5099
Lifen XuDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Leandra Ramin-WrightDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID 0000-0001-9505-7963
Otmar PfisterDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Gabriela M KusterDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland Gabriela.Kuster@usb.ch.ORCID 0000-0002-8209-4631
University of Basel · CHSIB Swiss Institute of Bioinformatics · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fms-like tyrosine kinase 3 (Flt3) is a regulator of hematopoietic progenitor cells and a target of tyrosine kinase inhibitors. Flt3-targeting tyrosine kinase inhibitors can have cardiovascular side effects. Flt3 and its ligand (Flt3L) are expressed in the heart, but little is known about their physiological functions. Here, we show that cardiac side population progenitor cells (SP-CPCs) from mice produce and are responsive to Flt3L. Compared with wild-type, flt3L

Indexed as

AnimalsAntigens, CD34BiomarkersCell DifferentiationCell Lineagefms-Like Tyrosine Kinase 3Gene Knockdown TechniquesHematopoietic Stem CellsImmunophenotypingMiceModels, BiologicalNeovascularization, PhysiologicSide-Population CellsStem CellsAntigens, CD34Biomarkersfms-Like Tyrosine Kinase 3

Identifiers

PMID34903561
PMCPMC8711848
OpenAlexW4200354683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.