ArticleBMJ open2021
Cost-effectiveness of an 8-week supervised education and exercise therapy programme for knee and hip osteoarthritis: a pre-post analysis of 16 255 patients participating in Good Life with osteoArthritis in Denmark (GLA:D).
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cost-Effectiveness of Treatments for Musculoskeletal Conditions Offered by Physiotherapists: A Systematic Review of Trial-Based Evaluations.Sports medicine - open · 2024Pooled it
- Rehabilitation and care after hip fracture: a cost-utility analysis of stepped-wedge cluster randomized trial.Journal of rehabilitation medicine · 2024Trial
- Trial
- From paradox to population impact: Rethinking strengthening in knee osteoarthritis - A state-of-the-art review.Osteoarthritis and cartilage open · 2026Review
- Implementing a guideline-based model of care for hip and knee osteoarthritis in Finland (FIN-OA): Protocol for a benchmarking-controlled trial.Osteoarthritis and cartilage open · 2026Article
- Patient-reported outcomes of a comprehensive management program for osteoarthritis of the hip and knee.Osteoarthritis and cartilage open · 2026Article
- 2050: An Arthroplasty Odyssey.Healthcare (Basel, Switzerland) · 2025Article
- Physical Therapists' Attitudes and Beliefs Regarding Treatment for Knee Osteoarthritis.Journal of clinical medicine · 2025Article
- Thick or Thin? Implications of Cartilage Architecture for Osteoarthritis Risk in Sedentary Lifestyles.Biomedicines · 2025Review
- General practitioners experience multi-level barriers to implementing recommended care for hip and knee osteoarthritis: a qualitative study.BMC primary care · 2024Article
- Referral, enrollment, and health care use in a comprehensive patient-centered management program for osteoarthritis of the hip and knee.Osteoarthritis and cartilage open · 2024Article
- Article
- The effect of geographic location and payor type on provincial-wide delivery of the GLA:D program for hip and knee osteoarthritis in Alberta, Canada.Osteoarthritis and cartilage open · 2023Article
- Smartphone-assisted training with education for patients with hip and/or knee osteoarthritis (SmArt-E): study protocol for a multicentre pragmatic randomized controlled trial.BMC musculoskeletal disorders · 2023Article
- Article
- The causal effect of two occupational factors on osteoarthritis and rheumatoid arthritis: a Mendelian randomization study.Frontiers in public health · 2023Article
- The GLA:D® Canada program for knee and hip osteoarthritis: A comprehensive profile of program participants from 2017 to 2022.PloS one · 2023Article
- Implementation of clinical guidelines for osteoarthritis together (IMPACT): protocol for a participatory health research approach to implementing high value care.BMC musculoskeletal disorders · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate 1-year cost-effectiveness of an 8-week supervised education and exercise programme delivered in primary care to patients with symptomatic knee or hip osteoarthritis (OA).
designA registry-based pre-post study linking patient-level data from the Good Life with osteoArthritis in Denmark (GLA:D) registry to national registries in Denmark. SETTING AND
participants16 255 patients with symptomatic knee or hip OA attending GLA:D.
interventionGLA:D is a structured supervised patient education and exercise programme delivered by certified physiotherapists and implemented in Denmark. OUTCOME MEASURES: Adjusted healthcare costs per Quality-Adjusted Life Year (QALY) gained from baseline to 1 year (ratio of change in healthcare costs to change in EuroQoL 5-Dimensions 5-Level questionnaire (EQ-5D)). All adjusted measures were estimated using a generalised estimating equation gamma regression model for repeated measures. Missing data on EQ-5D were imputed with Multiple Imputations (3 months: 23%; 1 year: 39 %).
resultsAdjusted change in healthcare cost was 298€ (95% CI: 206 to 419) and 640€ (95% CI: 400 to 1009) and change in EQ-5D was 0.035 (95% CI: 0.033 to 0.037) and 0.028 (95% CI: 0.025 to 0.032) for knee and hip patients, respectively. Hence estimated adjusted healthcare costs per QALY gained was 8497€ (95% CI: 6242 to 11 324) for knee and 22 568€ (95% CI: 16 000 to 31 531) for hip patients. In patients with high compliance, the adjusted healthcare costs per QALY gained was 5438€ (95% CI: 2758 to 9231) for knee and 17 330€ (95% CI: 10 041 to 29 364) for hip patients. Healthcare costs per QALY were below conventional thresholds for willingness-to-pay at 22 804€ (20 000£) and 43 979€ (US$50 000), except the upper limit of the 95% CI for hip patients which was in between the two thresholds.
conclusionsA structured 8-week supervised education and exercise programme delivered in primary care was cost-effective at 1 year in patients with knee or hip OA supporting large-scale implementation in clinical practice.
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Registered trials
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