Evidence map›Paper›PMID 34903345›Full record

ArticleThe American journal of cardiology2022

Usefulness of Restless Legs Symptoms to Predict Adverse Cardiovascular Outcomes in Men With Coronary Artery Disease.

Zakaria Almuwaqqat, Jeong Hwan Kim, Shabatun J Islam, Anurag Mehta, Syed Ahmad, Mohamad Wehbe, Katrina Hazim, Devinder Dhindsa, Nour Beydoun, Martha Lemma and 10 more

Open access · greenAbstract read
In one paragraph

Article in The American journal of cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 3 countries.

Zakaria AlmuwaqqatEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Jeong Hwan KimEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Shabatun J IslamEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Anurag MehtaEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Syed AhmadEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Mohamad WehbeEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Katrina HazimEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Devinder DhindsaEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Nour BeydounEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Martha LemmaEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Kiran EjazEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Syed AliEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Ayman AlkhoderEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Ayman S TahhanEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Eesha ZaheerEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Nishant VatsaEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
Yi-An KoEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine; Department of Biostatistics and Bioinformatics.
Laurence S SperlingEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine.
David RyeDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia.
Arshed A QuyyumiEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine. Electronic address: aquyyum@emory.edu.
Emory Healthcare · USEmory University · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Serious Hazards of Transfusion & Cellular Therapies: Mechanisms and InterventionP01HL086773 · NHLBI · EMORY UNIVERSITY · PI ROBACK, JOHN D · 2008 to 2019
$17.9M
Translational Research Core - Engagement and Behavior ChangeP30DK111024 · NIDDK · EMORY UNIVERSITY · PI Mohammed Kumail Ali · 2016 to 2026
$13.4M
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Cecile Delille Lahiri, Vasiliki Michopoulos · 2018 to 2026
$12.2M
Vascular Responses During Mental StressP01HL101398 · NHLBI · EMORY UNIVERSITY · PI QUYYUMI, ARSHED A · 2010 to 2015
$11.0M
J: NRSA Training CoreTL1TR002382 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Vasiliki Michopoulos · 2017 to 2026
$8.5M
Cell therapy for diabetic peripheral neurovascular complicationsDP3DK094346 · NIDDK · EMORY UNIVERSITY · PI CHENG, XIAODONG, YOON, YOUNG-SUP · 2011 to 2011
$6.1M
The role of the renin-angiotensin-endothelial pathway in ADRF1AG051633 · NIA · EMORY UNIVERSITY · PI HAJJAR, IHAB M, QUYYUMI, ARSHED A · 2015 to 2017
$6.0M
Adverse effects of RBC transfusions: A unifying hypothesisR01HL095479 · NHLBI · EMORY UNIVERSITY · PI ROBACK, JOHN D · 2009 to 2017
$5.2M
Metabolomics of subclinical and clinical cardiovascular diseaseP20HL113451 · NHLBI · EMORY UNIVERSITY · PI JONES, DEAN PAUL · 2012 to 2016
$4.3M
Hypertension, angiotensin receptor blockers, and cognition: effects and mechanismR01AG042127 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAJJAR, IHAB M · 2012 to 2017
$3.0M
Microvascular and sensory nerve function in non-Hispanic Blacks and WhitesR01HL141205 · NHLBI · GEORGIA STATE UNIVERSITY · PI WONG, BRETT · 2018 to 2021
$1.5M
American Heart Association-American Stroke Association 19POST34400057NCATS NIH HHS TL1 TR002382NCATS NIH HHS UL1 TR002378NHLBI NIH HHS F32 HL151163NHLBI NIH HHS P01 HL086773NHLBI NIH HHS P01 HL101398NHLBI NIH HHS P20 HL113451NHLBI NIH HHS R01 HL095479NHLBI NIH HHS R01 HL141205NHLBI NIH HHS R61 HL138657NIA NIH HHS R01 AG042127NIA NIH HHS RF1 AG051633NIA NIH HHS U54 AG062334NIDDK NIH HHS DP3 DK094346NIDDK NIH HHS P30 DK111024NINDS NIH HHS R01 NS064162
6 · The paper itself

Abstract

The relationship between restless legs syndrome (RLS) and cardiovascular disease remains enigmatic in the general population, and its prognostic value in patients with coronary artery disease (CAD) is unknown. In this study, the frequency of RLS-like symptoms was assessed using a validated instrument in 3,266 patients undergoing cardiac catheterization (mean age 64 years, 62% male, 23% Black, and 74% with obstructive CAD). Patients were followed for primary end points of cardiovascular death or incident myocardial infarction. Fine and Gray hazard models explored the association between RLS and incident events after adjustment for demographic and clinical risk factors. In the total cohort, 29% of patients reported mild (rare or sometimes) symptoms, and 15% of patients had moderate/severe (often to almost always) symptoms of RLS. Female sex (odds ratio [OR] 2.11, 95% confidence interval (CI), 1.68 to 2.57), body mass index (OR 1.12 per 5 kg/m

Indexed as

Cardiac CatheterizationCohort StudiesCoronary Artery DiseaseFemaleHumansMaleMiddle AgedMyocardial InfarctionOdds RatioPrognosisProportional Hazards ModelsRestless Legs SyndromeRisk Factors

Identifiers

PMID34903345
PMCPMC12922917
OpenAlexW4200327592

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.