Evidence map›Paper›PMID 34903299›Full record

SynthesisJournal of medical case reports2021

Delirium and other neuropsychiatric manifestations of COVID-19 infection in people with preexisting psychiatric disorders: a systematic review.

Emma A van Reekum, Tea Rosic, Anjali Sergeant, Nitika Sanger, Myanca Rodrigues, Reid Rebinsky, Balpreet Panesar, Eve Deck, Nayeon Kim, Julia Woo and 7 more

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of medical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Emma A van ReekumDepartment of Psychiatry and Behavioural Neurosciences, Clinician Investigator Program, McMaster University, Hamilton, Canada.
Tea RosicDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada.
Anjali SergeantMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
Nitika SangerMedical Science Graduate Program, McMaster University, Hamilton, Canada.
Myanca RodriguesHealth Research Methodology Graduate Program, McMaster University, Hamilton, Canada.
Reid RebinskyMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
Balpreet PanesarNeuroscience Graduate Program, McMaster University, Hamilton, Canada.
Eve DeckMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
Nayeon KimMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
Julia WooDepartment of Psychiatry and Behavioural Neurosciences, Clinician Investigator Program, McMaster University, Hamilton, Canada.
Alessia D'EliaNeuroscience Graduate Program, McMaster University, Hamilton, Canada.
Alannah HillmerNeuroscience Graduate Program, McMaster University, Hamilton, Canada.
Alexander DufortDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada.
Stephanie SangerHealth Sciences Library, McMaster University, Hamilton, Canada.
Lehana ThabaneDepartment of Health Research, Evidence and Impact, McMaster University, Hamilton, Canada.
Lawrence Mbuagbaw *Department of Health Research, Evidence and Impact, McMaster University, Hamilton, Canada.
Zainab Samaan *Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada. samaanz@mcmaster.ca.
McMaster University · CAImpact · CASt. Joseph’s Healthcare Hamilton · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPsychiatric disorders increase risk of neuropsychiatric disease and poor outcomes, yet little is known about the neuropsychiatric manifestations of COVID-19 in the psychiatric population. The primary objective is to synthesize neuropsychiatric outcomes of COVID-19 in people with preexisting psychiatric disorders.

methodsData were collected during an ongoing review of the impact of pandemics on people with existing psychiatric disorders. All study designs and gray literature were included. Medline, PsychInfo, CINAHL, EMBASE, and MedRx were searched from inception to September 1 2020. Risk of bias was assessed using a published tool that can accommodate all study types. Two independent authors screened the studies and extracted data. Data were narratively synthesized, as there were insufficient data to meta-analyze. Evidence was appraised according to GRADE.

resultsFour case reports were included, comprising 13 participants from three countries. Many large-sample, relevant papers were omitted for not reporting psychiatric history, despite reporting other comorbidities. Included participants (n = 13) were hospitalized with COVID-19 and appeared to meet criteria for delirium. Myoclonus, rigidity, and alogia were also reported. The most commonly reported preexisting psychiatric diagnoses were mood disorders, schizophrenia, and alcohol use disorder.

conclusionsPeople with preexisting psychiatric disorders may experience delirium, rigidity, myoclonus, and alogia during COVID-19 infection; although higher quality and longitudinal data are needed to better understand these phenomena. Relevant COVID-19 literature does not always report psychiatric history, despite heightened neuropsychiatric vulnerability within this population.

trial registrationPROSPERO (CRD42020179611).

Indexed as

COVID-19DeliriumBiasHumansPandemicsSARS-CoV-2Case reportsCOVID-19DeliriumInternal medicineMental disordersPandemicPsychiatric disorderSystematic review

Identifiers

PMID34903299
PMCPMC8667019
OpenAlexW4200286352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.