Evidence map›Paper›PMID 34903236›Full record

ArticleJournal of nanobiotechnology2021

A novel biomimetic nanomedicine system with anti-inflammatory and anti-osteoporosis effects improves the therapy efficacy of steroid-resistant nephrotic syndrome.

Jian Li, Mingyi Zhao, Xinying Xiang, Qingnan He, Rong Gui

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Biomimetic materials for medical applications.Chinese medical journal · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
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  10. COVID-19 inflammation and implications in drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2022
    Review
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jian LiDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Mingyi ZhaoDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Xinying XiangSchool of Life Sciences, Central South University, Changsha, 410013, China.
Qingnan HeDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. heqn2629@csu.edu.cn.
Rong GuiDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. guirong@csu.edu.cn.ORCID http://orcid.org/0000-0003-2501-0507
Central South University · CN

Funding

National Natural Science Foundation of China 82001165Natural Science Foundation of Hunan Province 2021JJ40926Natural Science Foundation of Hunan Province 2021JJ31002Talent Cultivation Project of the Third xiangya hospital of Central South University BJ202101the Changsha Municipal Natural Science Foundation kq2007056
6 · The paper itself

Abstract

Clinically, steroid-resistant nephrotic syndrome (SRNS) is always prolonged and difficult to treat and easily develops into end-stage renal disease, resulting in a low survival rate. Strategies to reverse steroid resistance and reduce the long-term use of high doses of steroid medicines are urgently needed. In this study, a novel nanoparticle drug system (Pm-GCH) with a core-shell structure was designed. Metal-organic frameworks, synthesized by glycyrrhizic acid (G) and calcium ions (Ca

Indexed as

Anti-Inflammatory AgentsBiomimetic MaterialsNanomedicineAnimalsBone and BonesCalcium ChlorideDrug ResistanceFemaleGlycyrrhizic AcidMetal-Organic FrameworksMiceNephrotic SyndromeOsteoporosisAnti-Inflammatory AgentsCalcium ChlorideGlycyrrhizic AcidMetal-Organic FrameworksBiomimeticGlycyrrhizic acidInflammatorySteroid-resistant nephrotic syndrome

Identifiers

PMID34903236
PMCPMC8670287
OpenAlexW4200181899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.