Evidence map›Paper›PMID 34903146›Full record

ArticleVirulence2021

Serum proteases prevent bacterial biofilm formation: role of kallikrein and plasmin.

Jesús Arenas, Zalan Szabo, Jelle van der Wal, Coen Maas, Tahira Riaz, Tone Tønjum, Jan Tommassen

Open access · goldAbstract read
In one paragraph

Article in Virulence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Jesús ArenasDepartment of Molecular Microbiology and Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands.
Zalan SzaboResearch and Development Department, U-Protein Express BV, Utrecht, The Netherlands.
Jelle van der WalDepartment of Molecular Microbiology and Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands.
Coen MaasDepartment of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.
Tahira RiazDepartment of Microbiology, University of Oslo, Oslo, Norway.
Tone TønjumDepartment of Microbiology, University of Oslo, Oslo, Norway.
Jan TommassenDepartment of Molecular Microbiology and Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands.
Utrecht University · NLUniversity of Oslo · NOUniversidad de Zaragoza · ESUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biofilm formation is a general strategy for bacterial pathogens to withstand host defense mechanisms. In this study, we found that serum proteases inhibit biofilm formation by

Indexed as

FibrinolysinNeisseria meningitidisAdhesins, BacterialBiofilmsKallikreinsAdhesins, BacterialFibrinolysinKallikreinsbiofilmsBordetella pertussiseDNAFHAIgA proteasekallikreinNaLPNeisseria meningitidisNHBAplasminserum proteases

Identifiers

PMID34903146
PMCPMC8677018
OpenAlexW4200479137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.