Evidence map›Paper›PMID 34903113›Full record

ReviewPalliative medicine2022

Practice review: Evidence-based and effective management of fatigue in patients with advanced cancer.

Emma J Chapman, Erica Di Martino, Zoe Edwards, Kathryn Black, Matthew Maddocks, Michael I Bennett

Open access · greenAbstract readReview
In one paragraph

Review in Palliative medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Mechanisms of simplified sitting Badunjin effects on symptom burden: a network-based cross-lagged analysis in advanced cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  2. Nurse-guided patient self-treatment in integrative oncology: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Trial
  3. Individualized Physiotherapy Improves Quality of Life and Symptom Burden in Advanced Cancer: A Quasi-Experimental Study.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Management of Fatigue in Patients with Advanced Cancer.Current treatment options in oncology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Emma J ChapmanAcademic Unit of Palliative Care, Leeds Institute of Health Sciences, Leeds, UK.ORCID 0000-0003-2859-2020
Erica Di MartinoAcademic Unit of Primary Care, Leeds Institute of Health Sciences, Leeds, UK.ORCID 0000-0001-6703-1707
Zoe EdwardsAcademic Unit of Palliative Care, Leeds Institute of Health Sciences, Leeds, UK.ORCID 0000-0001-6525-8190
Kathryn BlackSt Gemma's Hospice, Leeds, UK.
Matthew MaddocksCicely Saunders Institute of Palliative Care, Policy & Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK.ORCID 0000-0002-0189-0952
Michael I BennettAcademic Unit of Palliative Care, Leeds Institute of Health Sciences, Leeds, UK.ORCID 0000-0002-8369-8349
University of Leeds · GBChristie's · GBKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFatigue affects most patients living with advanced cancer and is a symptom that healthcare professionals can find difficult to manage.

aimTo provide healthcare professionals with a pragmatic overview of approaches to management of fatigue in patients with advanced cancer that are commonly recommended by guidelines and to evaluate evidence underpinning them.

designScoping review methodology was used to determine the strength of evidence supporting use of interventions recommended in management of fatigue in patients with advanced cancer. DATA SOURCES: National or international guidelines were examined if they described the management of fatigue in adult cancer patients and were written within the last 6 years (2015-2021) in English. The Cochrane Database of Systematic Reviews (January 2011-December 2021) was searched for 'cancer' AND 'fatigue' in title, abstract or keywords. A PubMed search was also made.

resultsEvidence indicates physical exercise interventions are effective and patients may benefit from energy conservation tactics. Evidence does not support use of psychostimulants such as methylphenidate. Limited data were found on efficacy of corticosteroids, psychological interventions, nutritional intervention, sleep optimization or complementary therapies for management of fatigue in advanced cancer.

conclusionWe recommend regular assessment, review and acknowledgement of the impact of fatigue. Exercise and energy conservation should be considered. Pharmacological interventions are not endorsed as a routine approach. Many interventions currently recommended by guidelines are not supported by a robust evidence base and further research on their efficacy is required.

Indexed as

FatigueNeoplasmsAdultHumansPractice Guidelines as TopicSystematic Reviews as Topicevidence-based practiceFatigueneoplasmsreviewterminal care

Identifiers

PMID34903113
PMCPMC8793304
OpenAlexW4200477488

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.