ArticlemBio2021
Evolutionary Processes Driving the Rise and Fall of
Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 32 citations in OpenAlex.
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- Time-associated phenotypic changes related to virulence and immune interaction of Staphylococcus aureus during relapsing infection within individual hosts.BMC infectious diseases · 2026Article
- Reduced MGE burden, virulence optimization, and acid stress tolerance shape the clonal succession of MRSA ST59.Science advances · 2026Article
- Emergence and genomic adaptation of the globally disseminated ST2250 lineage within theAntimicrobial agents and chemotherapy · 2026Article
- Comparative Genomic and Epidemiologic Analysis of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Genomic driver underlies clonal shift of methicillin-resistantEmerging microbes & infections · 2025Article
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- Methicillin-sensitiveMicrobial genomics · 2025Article
- Companions in antimicrobial resistance: examining transmission of common antimicrobial-resistant organisms between people and their dogs, cats, and horses.Clinical microbiology reviews · 2025Review
- Antivirulence Properties of Kuraridin Against Methicillin-ResistantBiomedicines · 2025Article
- Desiccation tolerance and reduced antibiotic resistance: Key drivers in ST239-III to ST22-IV MRSA clonal replacement at a Malaysian teaching hospital.International journal of medical microbiology : IJMM · 2024Article
- Multiomics analysis of Staphylococcus aureus ST239 strains resistant to virulent Herelleviridae phages.Scientific reports · 2024Article
- Methicillin-resistantJournal of medical microbiology · 2024Article
- Average nucleotide identity-basedmSystems · 2024Article
- The Epistemology of Bacterial Virulence Factor Characterization.Microorganisms · 2024Review
- Displacement of Hospital-Acquired, Methicillin-ResistantMicroorganisms · 2024Article
- Historic methicillin-resistant Staphylococcus aureus: expanding current knowledge using molecular epidemiological characterization of a Swiss legacy collection.Genome medicine · 2024Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Selection plays a key role in the spread of antibiotic resistance, but the evolutionary drivers of clinically important resistant strains remain poorly understood. Here, we use genomic analyses and competition experiments to study Staphylococcus aureus ST239, a prominent MRSA strain that is thought to have been formed by large-scale recombination between ST8 and ST30. Genomic analyses allowed us to refine the hybrid model for the origin of ST239 and to date the origin of ST239 to 1920 to 1945, which predates the clinical introduction of methicillin in 1959. Although purifying selection has dominated the evolution of ST239, parallel evolution has occurred in genes involved in antibiotic resistance and virulence, suggesting that ST239 has evolved toward an increasingly pathogenic lifestyle. Crucially, ST239 isolates have low competitive fitness relative to both ST8 and ST30 isolates, supporting the idea that fitness costs have driven the demise of this once-dominant pathogen strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.