Evidence map›Paper›PMID 34902584›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2022

No difference in risk of hospitalization between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway.

Lamprini Veneti, Beatriz Valcarcel Salamanca, Elina Seppälä, Jostein Starrfelt, Margrethe Larsdatter Storm, Karoline Bragstad, Olav Hungnes, Håkon Bøås, Reidar Kvåle, Line Vold and 3 more

Abstract read
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Drug Cocktail Formulation via Circuit Design.IEEE transactions on molecular, biological, and multi-scale communications · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Advances in the Omicron variant development.Journal of internal medicine · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lamprini VenetiDepartment of Infection Control and Preparedness, Norwegian Institute of Public Health, Oslo, Norway.
Beatriz Valcarcel SalamancaDepartment of Method Development and Analytics, Norwegian Institute of Public Health, Oslo, Norway.
Elina SeppäläDepartment of Infection Control and Vaccines, Norwegian Institute of Public Health, Oslo, Norway.
Jostein StarrfeltDepartment of Infection Control and Preparedness, Norwegian Institute of Public Health, Oslo, Norway.
Margrethe Larsdatter StormDepartment of Infectious Disease Registries, Norwegian Institute of Public Health, Oslo, Norway.
Karoline BragstadDepartment of Virology, Norwegian Institute of Public Health, Oslo, Norway.
Olav HungnesDepartment of Virology, Norwegian Institute of Public Health, Oslo, Norway.
Håkon BøåsDepartment of Infection Control and Preparedness, Norwegian Institute of Public Health, Oslo, Norway.
Reidar KvåleDepartment of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Line VoldDepartment of Infection Control and Preparedness, Norwegian Institute of Public Health, Oslo, Norway.
Karin NygårdDepartment of Infection Control and Preparedness, Norwegian Institute of Public Health, Oslo, Norway.
Eirik Alnes BuanesDepartment of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway; Norwegian Intensive Care and Pandemic Registry, Haukeland University Hospital, Bergen, Norway.
Robert WhittakerDepartment of Infection Control and Vaccines, Norwegian Institute of Public Health, Oslo, Norway. Electronic address: Robert.Whittaker@fhi.no.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo estimate the risk of hospitalization among reported cases of the Delta variant of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) compared with the Alpha variant in Norway, and the risk of hospitalization by vaccination status.

methodsA cohort study was conducted on laboratory-confirmed cases of SARS-CoV-2 in Norway, diagnosed between 3 May and 15 August 2021. Adjusted risk ratios (aRR) with 95% confidence intervals (CI) were calculated using multi-variable log-binomial regression, accounting for variant, vaccination status, demographic characteristics, week of sampling and underlying comorbidities.

resultsIn total, 7977 cases of the Delta variant and 12,078 cases of the Alpha variant were included in this study. Overall, 347 (1.7%) cases were hospitalized. The aRR of hospitalization for the Delta variant compared with the Alpha variant was 0.97 (95% CI 0.76-1.23). Partially vaccinated cases had a 72% reduced risk of hospitalization (95% CI 59-82%), and fully vaccinated cases had a 76% reduced risk of hospitalization (95% CI 61-85%) compared with unvaccinated cases.

conclusionsNo difference was found between the risk of hospitalization for Delta cases and Alpha cases in Norway. The results of this study support the notion that partially and fully vaccinated cases are highly protected against hospitalization with coronavirus disease 2019.

Indexed as

COVID-19SARS-CoV-2Cohort StudiesHospitalizationHumansNorwayAlphaDeltaHospitalizationNorwaySARS-CoV-2Variants of concern

Identifiers

PMID34902584
PMCPMC8664610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.