Evidence map›Paper›PMID 34902365›Full record

ArticleThe Journal of investigative dermatology2022

An Epidemiologic Analysis of Melanoma Overdiagnosis in the United States, 1975-2017.

Nicholas R Kurtansky, Stephen W Dusza, Allan C Halpern, Rebecca I Hartman, Alan C Geller, Ashfaq A Marghoob, Veronica M Rotemberg, Michael A Marchetti

Open access · greenAbstract read
In one paragraph

Article in The Journal of investigative dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. A systematic review of microsimulation models for skin cancer.BMC medical informatics and decision making · 2025
    Pooled it
  2. Pooled it
  3. Article
  4. Overdiagnosis of Melanoma In Situ.Journal of clinical medicine · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Environmental consequences of interacting effects of changes in stratospheric ozone, ultraviolet radiation, and climate: UNEP Environmental Effects Assessment Panel, Update 2024.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Deceptive Measures of "Success" in Early Cancer Detection.Current oncology (Toronto, Ont.) · 2024
    Review
  17. Article
  18. Observational
  19. Review
  20. Overdiagnosis in Melanoma Screening: Is It a Real Problem?Dermatology practical & conceptual · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nicholas R KurtanskyDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Stephen W DuszaDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Allan C HalpernDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Rebecca I HartmanDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Mass General Brigham, Boston, Massachusetts, USA; Melanoma Program, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Alan C GellerDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Ashfaq A MarghoobDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Veronica M RotembergDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Michael A MarchettiDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address: marchetm@mskcc.org.
Memorial Sloan Kettering Cancer Center · USBrigham and Women's Hospital · USHarvard University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The primary cause of the increase in melanoma incidence in the United States has been suggested to be overdiagnosis. We used Surveillance, Epidemiology, and End Result Program data from 1975 to 2017 to examine epidemiologic trends of melanoma incidence and mortality and better characterize overdiagnosis in white Americans. Over the 43-year period, incidence and mortality showed discordant temporal changes across population subgroups; trends most suggestive of overdiagnosis alone were present in females aged 55-74. Other groups showed mixed changes suggestive of overdiagnosis plus changes in underlying disease risk (decreasing risk in younger individuals and increasing risk in older males). Cohort effects were identified for male and female mortality and male incidence but were not as apparent for female incidence, suggesting that period effects have had a greater influence on changes in incidence over time in females. Encouraging trends included long-term declines in mortality in younger individuals and recent stabilization of invasive incidence in individuals aged 15-44 years and males aged 45-54 years. Melanoma in situ incidence, however, has continued to increase throughout the population. Overdiagnosis appears to be relatively greater in American females and for melanoma in situ.

Indexed as

MelanomaSkin NeoplasmsAgedCutaneous Malignant MelanomaFemaleHumansIncidenceMaleOverdiagnosisUnited States

Identifiers

PMID34902365
PMCPMC9187775
OpenAlexW4200610146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.