Evidence map›Paper›PMID 34902328›Full record

ArticleBiophysical journal2022

Cellular mechanics of wound formation in single cell layer under cyclic stretching.

Jiayi Xu, Xiangyu Xu, Xiaojun Li, Shijie He, Dechang Li, Baohua Ji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Cyclic stretch-regulated wound healing.Biophysical journal · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Three-dimensional chiral morphodynamics of chemomechanical active shells.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Article
  17. Mechanobiology in wound healing.Biophysical journal · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jiayi XuDepartment of Applied Mechanics, Beijing Institute of Technology, Beijing, China; Oujiang Laboratory, Zhejiang, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China; Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China.
Xiangyu XuDepartment of Applied Mechanics, Beijing Institute of Technology, Beijing, China; Oujiang Laboratory, Zhejiang, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China.
Xiaojun LiDepartment of Applied Mechanics, Beijing Institute of Technology, Beijing, China.
Shijie HeCenter for Engineering in Medicine and Surgery, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Dechang LiDepartment of Engineering Mechanics, Zhejiang University, Hangzhou, China. Electronic address: dcli@zju.edu.cn.
Baohua JiOujiang Laboratory, Zhejiang, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China; Department of Engineering Mechanics, Zhejiang University, Hangzhou, China. Electronic address: bhji@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wounds can be produced when cells and tissues are subjected to excessive forces, for instance, under pathological conditions or nonphysiological loading. However, the cellular behaviors in the wound formation process are not clear. Here we tested the behaviors of wound formation in the epithelial layer with an in-suit uniaxial stretching device. We found that the wound often nucleates at the position where the cells are dividing. The polarization direction of cells near the wound is preferentially along the wound edge, whereas the cells far from the wound are preferentially perpendicular to the stretching direction. The larger the wound area is, the higher is the aspect ratio of the cells around the wound. Increasing the cell density will strengthen the cell layer. The higher the cell density is, the smaller is the area of the wounds, and the weaker is the effect of stretching on the polarization of the cells. Furthermore, we built a coarse-grained cell model that can explicitly consider the elasticity and viscoelasticity of cells, cell-cell interaction, and cell active stress, by which we simulated the wound formation process and quantitatively analyzed the force and stress fields in the cell layer, particularly around the wound. These analyses reveal the cellular mechanisms of wound formation behaviors in the cell layer under stretching and shed useful light on tissue engineering and regenerative medicine for biomedical applications.

Indexed as

Mechanical PhenomenaTissue EngineeringElasticityStress, Mechanical

Identifiers

PMID34902328
PMCPMC8790211

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.