Evidence map›Paper›PMID 34902327›Full record

ArticleAmerican journal of ophthalmology2022

Bruch Membrane Opening Detection Accuracy in Healthy Eyes and Eyes With Glaucoma With and Without Axial High Myopia in an American and Korean Cohort.

Jasmin Rezapour, James A Proudfoot, Christopher Bowd, Jade Dohleman, Mark Christopher, Akram Belghith, Suzanne M Vega, Keri Dirkes, Min Hee Suh, Jost B Jonas and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 5 countries.

Jasmin RezapourFrom the Hamilton Glaucoma Center (J.R., J.A.P., C.B., J.D., M.C., A.B., S.M.V., K.D., R.S., N.A.A., R.N.W., L.M.Z.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA; Department of Ophthalmology (J.R.), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
James A ProudfootFrom the Hamilton Glaucoma Center (J.R., J.A.P., C.B., J.D., M.C., A.B., S.M.V., K.D., R.S., N.A.A., R.N.W., L.M.Z.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA.
Christopher BowdFrom the Hamilton Glaucoma Center (J.R., J.A.P., C.B., J.D., M.C., A.B., S.M.V., K.D., R.S., N.A.A., R.N.W., L.M.Z.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA.
Jade DohlemanFrom the Hamilton Glaucoma Center (J.R., J.A.P., C.B., J.D., M.C., A.B., S.M.V., K.D., R.S., N.A.A., R.N.W., L.M.Z.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA.
Mark ChristopherFrom the Hamilton Glaucoma Center (J.R., J.A.P., C.B., J.D., M.C., A.B., S.M.V., K.D., R.S., N.A.A., R.N.W., L.M.Z.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA.
Akram BelghithFrom the Hamilton Glaucoma Center (J.R., J.A.P., C.B., J.D., M.C., A.B., S.M.V., K.D., R.S., N.A.A., R.N.W., L.M.Z.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA.
Suzanne M VegaFrom the Hamilton Glaucoma Center (J.R., J.A.P., C.B., J.D., M.C., A.B., S.M.V., K.D., R.S., N.A.A., R.N.W., L.M.Z.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA.
Keri DirkesFrom the Hamilton Glaucoma Center (J.R., J.A.P., C.B., J.D., M.C., A.B., S.M.V., K.D., R.S., N.A.A., R.N.W., L.M.Z.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA.
Min Hee SuhDepartment of Ophthalmology (M.H.S.), Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
Jost B JonasDepartment of Ophthalmology (J.B.J.), Medical Faculty Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany; Institute of Molecular and Clinical Ophthalmology Basel (J.B.J.), Basel, Switzerland; Institute of Clinical and Scientific Ophthalmology and Acupuncture Jonas & Panda (J.B.J.), Heidelberg, Germany.
Leslie HymanWills Eye Hospital (L.H.), Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Massimo A FazioDepartment of Ophthalmology and Vision Science (M.A.F.), School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Biomedical Engineering (M.A.F.), School of Engineering, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ruti SellaFrom the Hamilton Glaucoma Center (J.R., J.A.P., C.B., J.D., M.C., A.B., S.M.V., K.D., R.S., N.A.A., R.N.W., L.M.Z.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA; Department of Ophthalmology (R.S.), Rabin Medical Center, Petah Tikva, Israel; Sackler Faculty of Medicine (R.S.), Tel Aviv University, Tel Aviv, Israel.
Natalie A AfshariFrom the Hamilton Glaucoma Center (J.R., J.A.P., C.B., J.D., M.C., A.B., S.M.V., K.D., R.S., N.A.A., R.N.W., L.M.Z.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA.
Robert N WeinrebFrom the Hamilton Glaucoma Center (J.R., J.A.P., C.B., J.D., M.C., A.B., S.M.V., K.D., R.S., N.A.A., R.N.W., L.M.Z.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA.
Linda M ZangwillFrom the Hamilton Glaucoma Center (J.R., J.A.P., C.B., J.D., M.C., A.B., S.M.V., K.D., R.S., N.A.A., R.N.W., L.M.Z.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA. Electronic address: lzangwill@health.ucsd.edu.
University of California San Diego · USHeidelberg University · DEInje University Haeundae Paik Hospital · KRJohannes Gutenberg University Mainz · DETel Aviv University · ILThomas Jefferson University · USUniversity of Alabama at Birmingham · US

Funding

African Descent And Glaucoma Evaluation Study (ADAGES)U10EY014267 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2002 to 2010
$13.2M
Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced DiseaseR01EY027510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2017 to 2026
$5.3M
Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography AngiographyR01EY029058 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEINREB, ROBERT N · 2018 to 2024
$4.2M
African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma ProgressionR01EY019869 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2010 to 2014
$2.8M
African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progressionR01EY026574 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAZIO, MASSIMO ANTONIO, GIRKIN, CHRISTOPHER ANTHONY · 2017 to 2020
$2.6M
NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY019869NEI NIH HHS R01 EY026574NEI NIH HHS R01 EY027510NEI NIH HHS R01 EY029058NEI NIH HHS U10 EY014267
6 · The paper itself

Abstract

purposeTo determine the predictors of Bruch membrane opening (BMO) location accuracy and the visibility of the BMO location in glaucoma and healthy individuals with and without axial high myopia.

designCross-sectional study.

methodsHealthy eyes and eyes with glaucoma from an American study and a Korean clinic population were classified into 2 groups: those with no axial high myopia (axial length [AL] <26 mm) and those with axial high myopia (AL ≥26 mm). The accuracy of the automated BMO location on optic nerve head Spectralis optical coherence tomography radial scans was assessed by expert reviewers.

resultsFour hundred thirty-eight non-highly myopic eyes (263 subjects) and 113 highly myopic eyes (81 subjects) were included. In healthy eyes with and without axial high myopia, 9.1% and 1.7% had indiscernible BMOs while 54.5% and 87.6% were accurately segmented, respectively. More than a third (36.4%) and 10.7% of eyes with indiscernible BMOs were manually correctable (respectively, P = .017). In eyes with glaucoma with and without high myopia, 15.0% and 3.2% had indiscernible BMOs, 55.0% and 38.2% were manually corrected, and 30.0% and 58.7% were accurately segmented without the need for manual correction (respectively, P = .005). Having axial high myopia, a larger AL, a larger BMO tilt angle, a lower BMO ovality index (more oval), and a glaucoma diagnosis were significant predictors of BMO location inaccuracy in multivariable logistic regression analysis.

conclusionsAs BMO location inaccuracy was 2.4 times more likely in eyes with high axial myopia regardless of diagnosis, optical coherence tomography images of high myopes should be reviewed carefully, and when possible, BMO location should be corrected before using optic nerve head scan results for the clinical management of glaucoma.

Indexed as

GlaucomaMyopiaBruch MembraneCross-Sectional StudiesHumansIntraocular PressureNerve FibersRepublic of KoreaRetinal Ganglion CellsTomography, Optical CoherenceVisual Fields

Identifiers

PMID34902327
PMCPMC9754118
OpenAlexW4200209301

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.