Evidence map›Paper›PMID 34902137›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Gas-Phase Ion-Ion Reactions for Lipid Identification in Biological Tissue Sections.

Boone M Prentice

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Isomer-Resolved Mass Spectrometry Imaging of Acidic Phospholipids.Journal of the American Society for Mass Spectrometry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Boone M PrenticeDepartment of Chemistry, University of Florida, Gainesville, FL, USA. booneprentice@chem.ufl.edu.
University of Florida · US

Funding

Imaging mass spectrometry at isomeric chemical resolution using gas phase ion/ion reactionsR01GM138660 · NIGMS · UNIVERSITY OF FLORIDA · PI PRENTICE, BOONE M. · 2020 to 2024
$1.6M
NIGMS NIH HHS R01 GM138660
6 · The paper itself

Abstract

The unambiguous identification of isobaric (i.e., same nominal mass) and isomeric (i.e., same exact mass) lipids remains a challenging yet vital aspect of imaging mass spectrometry (IMS) workflows. This chapter presents a methodology for the preparation of biological tissue samples and the use of a hybrid mass spectrometer to perform gas-phase charge inversion ion/ion reactions for improved lipid identification. This gas-phase ion/ion reaction method provides lipid structural information beyond what can be obtained via conventional tandem mass spectrometry (MS/MS) experiments. While this procedure is described here for the identification of phosphatidylcholine (PC) analyte cations using 1,4-phenylenedipropionic acid reagent dianions, it can readily be generalized to perform a diverse array of ion/ion reaction chemistries.

Indexed as

Diagnostic Tests, RoutineHistological TechniquesIsomerismLipidsPhosphatidylcholinesTandem Mass SpectrometryLipidsPhosphatidylcholinesGas-phaseImaging mass spectrometryIon/ion reactionsLipid identification

Identifiers

PMID34902137
PMCPMC9148664
OpenAlexW4200110726

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.