ArticleSkin health and disease2021
Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID-19.
Article in Skin health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Male-pattern hair loss: Comprehensive identification of the associated genes as a basis for understanding pathophysiology.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2023Article
- Comorbidities in Androgenetic Alopecia: A Comprehensive Review.Dermatology and therapy · 2022Review
- Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID-19.Skin health and disease · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMale androgenetic alopecia (AGA) has been implicated as a putative risk factor in severe COVID-19 based on high incidences of advanced AGA in male hospitalized COVID-19 patients. Research further suggests that androgen signalling, which plays a central role in AGA aetiology, promotes SARS-CoV-2 infection and is associated with severe COVID-19 symptoms in men.
objectivesWe aimed to systematically investigate a potential association between AGA and COVID-19 both on an epidemiological and a genetic level in a large single-population cohort.
methodsWe performed regression, genetic correlation and polygenic risk score (PRS) analyses using data from the UK Biobank and published GWAS data on AGA and COVID-19.
resultsOur analyses did not reveal any significant epidemiological or genome-wide genetic association between AGA and severe COVID-19. Pathway-based PRS analyses however revealed a significant association in specific pathways, namely vitamin metabolism, natural killer cell-mediated cytotoxicity, WNT signalling and aryl hydrocarbon receptor signalling. LIMITATIONS: We restricted our analyses to the white British population and used self-reported AGA status. Sample size may be a limitation in our regression and PRS analyses.
conclusionsOur data yield no evidence for an epidemiological association between AGA and COVID-19 but suggest that a shared genetic basis for both traits exists in specific pathways.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.