Evidence map›Paper›PMID 34901948›Full record

ArticleNeurotrauma reports2021

Transcranial Laser Therapy Does Not Improve Cognitive and Post-Traumatic Stress Disorder-Related Behavioral Traits in Rats Exposed to Repetitive Low-Level Blast Injury.

Georgina Perez Garcia, Gissel M Perez, Alena Otero-Pagan, Rania Abutarboush, Usmah Kawoos, Rita De Gasperi, Miguel A Gama Sosa, Dylan Pryor, Patrick R Hof, David G Cook and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Georgina Perez GarciaResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA.
Gissel M PerezResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA.
Alena Otero-PaganResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA.
Rania AbutarboushDepartment of Neurotrauma, Naval Medical Research Center, Silver Spring, Maryland, USA.
Usmah KawoosDepartment of Neurotrauma, Naval Medical Research Center, Silver Spring, Maryland, USA.
Rita De GasperiResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA.
Miguel A Gama SosaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Dylan PryorResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA.
Patrick R HofNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
David G CookGeriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington, USA.
Sam GandyResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA.
Stephen T AhlersDepartment of Neurotrauma, Naval Medical Research Center, Silver Spring, Maryland, USA.
Gregory A ElderDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Funding

RRD VA I01 RX002660RRD VA I21 RX003019
6 · The paper itself

Abstract

Many military veterans who experienced blast-related traumatic brain injuries (TBIs) in the conflicts in Iraq and Afghanistan suffer from chronic cognitive and mental health problems, including post-traumatic stress disorder (PTSD). Transcranial laser therapy (TLT) uses low-power lasers emitting light in the far- to near-infrared ranges. Beneficial effects of TLT have been reported in neurological and mental-health-related disorders in humans and animal models, including TBI. Rats exposed to repetitive low-level blast develop chronic cognitive and PTSD-related behavioral traits. We tested whether TLT treatment could reverse these traits. Rats received a 74.5-kPa blast or sham exposures delivered one per day for 3 consecutive days. Beginning at 34 weeks after blast exposure, the following groups of rats were treated with active or sham TLT: 1) Sham-exposed rats (

Indexed as

blastpost-traumatic stress disorderrattranscranial laser therapytraumatic brain injury

Identifiers

PMID34901948
PMCPMC8655798

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.