Evidence map›Paper›PMID 34901941›Full record

ArticleNeurotrauma reports2021

Insulin-Like Growth Factor-2 (IGF-2) Does Not Improve Memory in the Chronic Stage of Traumatic Brain Injury in Rodents.

John B Redell, Mark E Maynard, Kimberly N Hood, Anthony N Moore, Jing Zhao, Pramod K Dash

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

John B RedellDepartment of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA.
Mark E MaynardDepartment of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA.
Kimberly N HoodDepartment of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA.
Anthony N MooreDepartment of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA.
Jing ZhaoDepartment of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA.
Pramod K DashDepartment of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA.
The University of Texas Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent cognitive impairment(s) can be a significant consequence of traumatic brain injury (TBI) and can markedly compromise quality of life. Unfortunately, identifying effective treatments to alleviate memory impairments in the chronic stage of TBI has proven elusive. Several studies have demonstrated that insulin-like growth factor-2 (IGF-2) can enhance memory in both normal animals and in experimental models of disease. In this study, we questioned whether IGF-2, when administered before learning, could enhance memory performance in the chronic stage of TBI. Male C57BL/6 mice (

Indexed as

cortical impact injuryfear extinctionnovel object recognitionwater maze

Identifiers

PMID34901941
PMCPMC8655797
OpenAlexW3206611536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.