Evidence map›Paper›PMID 34901928›Full record

ReviewFrontiers in genome editing2021

Prime Editing for Inherited Retinal Diseases.

Bruna Lopes da Costa, Sarah R Levi, Eric Eulau, Yi-Ting Tsai, Peter M J Quinn

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in genome editing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Ciliary Defects in Inherited Retinal Diseases.Advanced genetics (Hoboken, N.J.) · 2026
    Review
  3. Article
  4. Review
  5. Rekindling Vision: Innovative Strategies for Treating Retinal Degeneration.International journal of molecular sciences · 2025
    Review
  6. Mutation Specific Treatments for Inherited Retinal Diseases.Advances in experimental medicine and biology · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Toward Retinal Organoids in High-Throughput.Cold Spring Harbor perspectives in medicine · 2024
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Therapeutic Gene Editing in Inherited Retinal Disorders.Cold Spring Harbor perspectives in medicine · 2023
    Review
  16. Article
  17. Prime Editing Strategy to Install the PRPH2 c.828+1G>A Mutation.Advances in experimental medicine and biology · 2023
    Article
  18. Gene therapies in pediatric ophthalmology.Frontiers in ophthalmology · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Bruna Lopes da CostaDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, NY, United States.
Sarah R LeviDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, NY, United States.
Eric EulauCollege of Arts and Sciences, Syracuse University, New York, NY, United States.
Yi-Ting TsaiDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, NY, United States.
Peter M J QuinnDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, NY, United States.
Columbia University · USColumbia University Irving Medical Center · USSyracuse University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inherited retinal diseases (IRDs) are chronic, hereditary disorders that lead to progressive degeneration of the retina. Disease etiology originates from a genetic mutation-inherited or

Indexed as

adeno-associated viral (AAV) vectorsCRISPR/Cas9 systemsgene editinginherited retinal diseases (IRD)Ophthalmologyprime editingretinal degeneration

Identifiers

PMID34901928
PMCPMC8656220
OpenAlexW3216541111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.