Evidence map›Paper›PMID 34901898›Full record

ArticleThe Lancet. Microbe2021

Interaction of

Joseph J Wanford, Ryan G Hames, David Carreno, Zydrune Jasiunaite, Wen Y Chung, Fabio Arena, Vincenzo Di Pilato, Kornelis Straatman, Kevin West, Robeena Farzand and 7 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in The Lancet. Microbe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05255042 (Tissue Models for Liver Disease), which is not on this map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05255042 completednot on this map

Tissue Models for Liver Disease

TypeobservationalSponsorUniversity of LeicesterRan2021 to 2025Enrolled36ConditionsLiver DiseasesArmsorgan and tissue sample collection only
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Connections betweenInfection and immunity · 2026
    Article
  9. Modulation of macrophage survival duringFrontiers in cellular and infection microbiology · 2026
    Review
  10. Article
  11. Antibiotics accumulate inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Infection and immunity · 2025
    Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Enhanced invasion and survival of antibiotic- resistantFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 2 countries.

Joseph J WanfordDepartment of Genetics and Genome Biology, University of Leicester, Leicester, UK.
Ryan G HamesDepartment of Genetics and Genome Biology, University of Leicester, Leicester, UK.
David CarrenoDepartment of Genetics and Genome Biology, University of Leicester, Leicester, UK.
Zydrune JasiunaiteDepartment of Genetics and Genome Biology, University of Leicester, Leicester, UK.
Wen Y ChungDepartment of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK.
Fabio ArenaDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Vincenzo Di PilatoDepartment of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy.
Kornelis StraatmanAdvanced Imaging Facility, University of Leicester, Leicester, UK.
Kevin WestDepartment of Pathology, University Hospitals of Leicester, Leicester, UK.
Robeena FarzandDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
Mariagrazia PizzaGlaxoSmithKline, Siena, Italy.
Luisa Martinez-PomaresSchool of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, UK.
Peter W AndrewDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
E Richard MoxonDepartment of Paediatrics, University of Oxford, Oxford, UK.
Ashley R DennisonDepartment of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK.
Gian Maria RossoliniDepartment of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy.
Marco R OggioniDepartment of Genetics and Genome Biology, University of Leicester, Leicester, UK.
University of Leicester · GBUniversity Hospitals of Leicester NHS Trust · GBAzienda Ospedaliero-Universitaria Careggi · ITDon Carlo Gnocchi Foundation · ITGlaxoSmithKline (Italy) · ITUniversity of Florence · ITUniversity of Nottingham · GBUniversity of Oxford · GB

Funding

Biotechnology and Biological Sciences Research Council BB/S507052/1Medical Research Council
6 · The paper itself

Abstract

backgroundHypervirulent

methodsIn this exploratory investigation, to study the pathophysiology of abscess formation, mice were intravenously infected with 10

findingsWe show that hv

interpretationThese findings show subversion of innate immune processes in the liver by

fundingUniversity of Oxford and a Royal Society Wolfson grant funded biosafety facility.

Indexed as

Klebsiella InfectionsLiver AbscessAnimalsKlebsiella pneumoniaeMacrophagesMicePerfusionSwineVirulence

Identifiers

PMID34901898
PMCPMC8641047
OpenAlexW3206426398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.