ArticleSchizophrenia bulletin open2021
What is the Best Latent Structure of Negative Symptoms in Schizophrenia? A Systematic Review.
Article in Schizophrenia bulletin open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Discrepancies between ideal and actual affect predict negative symptoms in schizophrenia in daily life: An ecological momentary assessment study.Psychiatry research · 2026Article
- Associations between negative symptoms and resting-state functional connectivity within social brain networks among individuals with early psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Neuroanatomical Correlates of Negative Symptoms in Schizophrenia.bioRxiv : the preprint server for biology · 2025Article
- Accelerated Optimized Protocol of Intermittent Theta-Burst Stimulation for Negative Symptoms in Schizophrenia (ACTh-NS): A Randomized, Double-Blind, Sham-Controlled Study Design.Brain sciences · 2025Article
- The Negative Symptom Inventory-Psychosis Risk (NSI-PR): Psychometric Validation of the Final 11-Item Version.Schizophrenia bulletin · 2025Article
- Psychometric properties of the Clinical Assessment Interview for Negative Symptoms (CAINS) in patients with depression and its relationship to affective symptoms.Annals of general psychiatry · 2023Article
- Development and Validation of the Negative Symptom Inventory-Psychosis Risk.Schizophrenia bulletin · 2023Article
- Negative dimension stability across clinical stages and sociodemographic characteristics in schizophrenia.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2022Article
- Symptom Structure in Schizophrenia: Implications of Latent Variable Modeling vs Network Analysis.Schizophrenia bulletin · 2022Article
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Authors and funding
9 authors.
Funding
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Abstract
backgroundDetermining the best latent structure of negative symptoms in schizophrenia could benefit assessment tools, neurobiological research, and targeted interventions. However, no review systematically evaluated studies that assessed and validated latent models of negative symptoms.
objectiveTo identify and evaluate existing latent structure models in the literature of negative symptoms and to determine the best model.
methodSystematic search of MEDLINE, EMBASE, and Scopus on July 19, 2020, for confirmatory factor analysis models of negative symptoms in patients with schizophrenia. The available evidence was assessed through 2 sets of criteria: (1) study design quality-based on negative symptoms assessment and modeling strategy and (2) psychometric quality and model fit-based on fit indices and factor definition quality.
resultsIn total, 22 studies (
conclusionsOur review points out that the 5-factor and hierarchical models represent the best latent structure of negative symptoms, but the immaturity of the relevant current literature may affect the robustness of this conclusion. Future studies should address current limitations regarding psychometric properties and also address biological and clinical validity to refine available models.
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