Evidence map›Paper›PMID 34901751›Full record

ArticleHematology, transfusion and cell therapy

SARS-COV-2 screening in allogeneic hematopoietic stem cell donors: Implications for the evaluation process and eligibility.

Roberto Crocchiolo, Francesco Alfarano, Elisabetta Volpato, Mariateresa Pugliano, Irene Cuppari, Anna Maria Mazza, Laura Bellio, Diana Fanti, Chiara Vismara, Francesco Scaglione and 6 more

Open access · diamondAbstract read
In one paragraph

Article in Hematology, transfusion and cell therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Is SARS-CoV-2 screening still necessary before hematopoietic stem cell donation? Observations from a single center and review of the literature.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Roberto CrocchioloASST Grande Ospedale Metropolitano Niguarda, Milano, Italy. Electronic address: roberto.crocchiolo@ospedaleniguarda.it.
Francesco AlfaranoASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Elisabetta VolpatoASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Mariateresa PuglianoASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Irene CuppariASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Anna Maria MazzaASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Laura BellioASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Diana FantiASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Chiara VismaraASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Francesco ScaglioneASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Nicoletta SacchiItalian Bone Marrow Donor Registry, Ospedale Galliera, Genova, Italy.
Simona PollichieniItalian Bone Marrow Donor Registry, Ospedale Galliera, Genova, Italy.
Lia MeleHLA Laboratory, A.O. SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
Elisa DiralASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Giovanni GrilloASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Silvano RossiniASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITEnte Ospedaliero Ospedali Galliera · ITAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSoon after the onset of the SARS-CoV-2 pandemic, viral screening by nasopharyngeal swab became mandatory for allogeneic hematopoietic stem cell (HSC) donor eligibility.

methodsWe described our monocenter experience with allogeneic HSC donors from February 1 to the October 31, 2020 to verify whether the introduction of SARS-CoV-2 screening altered the donor eligibility and/or entailed a prolongation of the evaluation process.

resultsA total of 21 allogeneic HSC donors were screened during the above-mentioned period upon request by the local transplant physicians or by the Italian Bone Marrow Donor Registry; among the HSC donors (

conclusionThe mandatory SARS-CoV-2 screening in allogeneic HSC donors allowed for the detection of 6% positivity in this monocenter series over a 9-month period. Despite the inconvenience of this unexpected non-eligibility, the exclusion of a SARS-CoV-2 positive donor represented an important safety measure for the donor, with respect to a new and still partially unknown virus. The screening did not alter the length of the donor evaluation and thus, did not cause a delay in the eligibility process.

Indexed as

DonorsEligibilityHematopoietic stem cellsSars-cov-2Screening

Identifiers

PMID34901751
PMCPMC8648663
OpenAlexW4200046155

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.