Evidence map›Paper›PMID 34901585›Full record

ArticleCurrent opinion in biomedical engineering2021

Breast cancer immunotherapy: current biomarkers and the potential of

Melissa C Skala, Jose M Ayuso, Mark E Burkard, Dustin A Deming

Abstract read
In one paragraph

Article in Current opinion in biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Vaccines in Breast Cancer: Challenges and Breakthroughs.Diagnostics (Basel, Switzerland) · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Melissa C SkalaMorgridge Institute for Research, Madison, WI, USA.
Jose M AyusoDepartment of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, USA.
Mark E BurkardUniversity of Wisconsin Carbone Cancer Center, Madison, Wisconsin.
Dustin A DemingUniversity of Wisconsin Carbone Cancer Center, Madison, Wisconsin.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Optical imaging to predict cell-level genetic heterogeneity and treatment sensitivity in colorectal cancerR37CA226526 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI DEMING, DUSTIN A · 2018 to 2024
$4.2M
Optical imaging of pancreas cancer organoids for drug development and personalized treatmentR01CA211082 · NCI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI SKALA, MELISSA CAROLINE · 2017 to 2021
$3.5M
Impact of chromosomal instability on sensitivity to microtubule-targeting drugs in breast cancerR01CA234904 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E, WEAVER, BETH A · 2019 to 2023
$2.7M
(PQ7) Quantitative in vivo optical imaging of tumor heterogeneityR01CA205101 · NCI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI SKALA, MELISSA CAROLINE · 2016 to 2020
$1.9M
Single Cell Profiling To Define Biomarkers Of Photoreceptor Dysfunction After Gene Editing Within PSC-Derived OrganoidsU01EY032333 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI GAMM, DAVID M, ROY, SUSHMITA · 2020 to 2022
$1.8M
Cellular-level Optical Metabolic Imaging to Predict Drug Response in CancerR01CA185747 · NCI · VANDERBILT UNIVERSITY · PI SKALA, MELISSA CAROLINE · 2014 to 2019
$1.6M
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA185747NCI NIH HHS R01 CA205101NCI NIH HHS R01 CA211082NCI NIH HHS R01 CA234904NCI NIH HHS R37 CA226526NEI NIH HHS U01 EY032333
6 · The paper itself

Abstract

Breakthroughs in metastatic breast cancer care require new model systems that can identify the unique features and vulnerabilities of each cancer. Primary tumor cultures are proposed to efficiently screen multiple treatment options in a patient-specific strategy to maximize therapeutic benefit, minimize toxicity, and enable mechanistic insights that inspire future biomarkers for patient selection. To realize the potential of patient-specific cultures, new tools are needed to capture cell-by-cell variability in behavior and dynamic response to treatments in living 3D specimens. Potential bioengineering tools that can achieve this include optical microscopy to image single-cell dynamics and microphysiological

Identifiers

PMID34901585
PMCPMC8654237

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.