Evidence map›Paper›PMID 34901571›Full record

ArticleKidney international reports2021

Adult Living-Donor Kidney Transplantation, Donor Age, and Donor-Recipient Age.

Takahisa Hiramitsu, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Yutaka Matsuoka, Norihiko Goto, Toshihiro Ichimori, Shunji Narumi, Asami Takeda, Takaaki Kobayashi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Observational
  2. Article
  3. Ambulance Service Utilization by Kidney Transplant Recipients.Canadian journal of kidney health and disease · 2025
    Article
  4. Article
  5. Article
  6. Survival Advantage Comparing Older Living Donor Versus Standard Criteria Donor Kidney Transplants.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  7. Comparison of Kidney Graft Function and Survival in an Emulated Trial With Living Donors and Brain-Dead Donors.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Takahisa HiramitsuDepartment of Transplant and Endocrine Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Aichi, Japan.
Toshihide TomosugiDepartment of Transplant and Endocrine Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Aichi, Japan.
Kenta FutamuraDepartment of Transplant and Endocrine Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Aichi, Japan.
Manabu OkadaDepartment of Transplant and Endocrine Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Aichi, Japan.
Yutaka MatsuokaDepartment of Renal Transplant Surgery, Masuko Memorial Hospital, Aichi, Japan.
Norihiko GotoDepartment of Transplant and Endocrine Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Aichi, Japan.
Toshihiro IchimoriDepartment of Transplant and Endocrine Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Aichi, Japan.
Shunji NarumiDepartment of Transplant and Endocrine Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Aichi, Japan.
Asami TakedaDepartment of Nephrology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Aichi, Japan.
Takaaki KobayashiDepartment of Renal Transplant Surgery, Aichi Medical University School of Medicine, Aichi, Japan.
Kazuharu UchidaDepartment of Renal Transplant Surgery, Masuko Memorial Hospital, Aichi, Japan.
Yoshihiko WataraiDepartment of Transplant and Endocrine Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Aichi, Japan.
Japanese Red Cross Nagoya Daini Hospital · JPNagoya Memorial Hospital · JPAichi Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOwing to organ shortage, the number of kidney transplantation (KT) involving older adult living donors is increasing. We aimed to investigate the effects of living-donor age and donor-recipient age differences on KT outcomes.

methodsThis single-center, retrospective cohort study involved 853 adult LDKTs performed between January 2008 and December 2018. Recipients were stratified into the following 5 groups based on donor age and donor-recipient age difference: donor age, 30 to 49 years and age difference, -10 to 15 years; donor age, 50 to 69 years and age difference, -10 to 15 years; donor age, 50 to 69 years and age difference, 15 to 40 years; donor age, 70 to 89 years and age difference, -10 to 15 years; and donor age, 70 to 89 years and age difference, 15 to 40 years (groups 1, 2, 3, 4, and 5, respectively). As a primary outcome, the risk of graft loss was investigated. The secondary outcomes were postoperative estimated glomerular filtration rates (eGFRs) and mortality rates of recipients.

resultsGroup 4, representing KT between older adult donors and older adult recipients, had the highest graft loss risk and mortality. The eGFRs of the recipients from donors aged 70 to 89 years (groups 4 and 5) were significantly lower than those from donors in the other groups. Although the differences in the eGFR between groups 4 and 5 were not significant, the eGFR of group 4 was lower than that of group 5 at 6 months post-KT.

conclusionLDKTs from older adult donors to older adult recipients resulted in the worst graft survival and mortality rates.

Indexed as

donor agedonor-recipient age differencegraft biopsygraft lossliving-donor kidney transplantationmortality

Identifiers

PMID34901571
PMCPMC8640566
OpenAlexW3206350522

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.