ArticleBioactive materials2022
Experimental study of a 3D printed permanent implantable porous Ta-coated bone plate for fracture fixation.
Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dynamic Fracture Fixation Plates: A Systematic Review of Evolving Design Approaches.Annals of biomedical engineering · 2025Pooled it
- Magnetron sputtering to enhance bone integration of tantalum-coated titanium implants: an in vitro and in vivo analysis.BMC biotechnology · 2025Article
- Layered Gradient Rhombic Dodecahedron Composite Structures for Biomimetic Bone Fabricated via Selective Laser Melting.Micromachines · 2025Article
- [Research progress in three-dimensional-printed bone scaffolds combined with vascularized tissue flaps for segmental bone defect reconstruction].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Review
- 3D-printed artificial bone scaffolds: the design of materials, the incorporation of bioactive substances, and the integration of vascularized tissue flaps.Frontiers in bioengineering and biotechnology · 2025Review
- Progress in the Application of Porous Tantalum Metal in Hip Joint Surgery.Orthopaedic surgery · 2024Review
- An adaptive biodegradable zinc alloy with bidirectional regulation of bone homeostasis for treating fractures and aged bone defects.Bioactive materials · 2024Article
- Design considerations for patient-specific bone fixation plates: a literature review.Medical & biological engineering & computing · 2023Review
- 3D printing metal implants in orthopedic surgery: Methods, applications and future prospects.Journal of orthopaedic translation · 2023Review
- Combination therapy with BMSCs‑exosomes and porous tantalum for the repair of femur supracondylar defects.Molecular medicine reports · 2023Article
- Contributions of Resin Cast Etching to Visualising the Osteocyte Lacuno-Canalicular Network Architecture in Bone Biology and Tissue Engineering.Calcified tissue international · 2023Review
- A novel biomimetic trabecular bone metal plate for bone repair and osseointegration.Regenerative biomaterials · 2023Article
- Preparation, modification, and clinical application of porous tantalum scaffolds.Frontiers in bioengineering and biotechnology · 2023Review
- Translation of biomaterials from bench to clinic.Bioactive materials · 2022Article
- Advances in surface modification of tantalum and porous tantalum for rapid osseointegration: A thematic review.Frontiers in bioengineering and biotechnology · 2022Review
- Fabrication and Characterization of New Functional Graded Material Based on Ti, Ta, and Zr by Powder Metallurgy Method.Materials (Basel, Switzerland) · 2021Article
- Functionally graded additive manufacturing for orthopedic applications.Journal of orthopaedicsArticle
- Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metal plates have always been the gold standard in the clinic for internal fracture fixation due to their high strength advantages. However, high elastic modulus can cause stress shielding and lead to bone embrittlement. This study used an electron beam melting method to prepare personalized porous Ti6Al4V (pTi) bone plates. Then, chemical vapor deposition (CVD) technology coats tantalum (Ta) metal on the pTi bone plates. The prepared porous Ta-coated bone plate has an elastic modulus similar to cortical bone, and no stress shielding occurred. In vitro experiments showed that compared with pTi plates, Ta coating significantly enhances the attachment and proliferation of cells on the surface of the scaffold. To better evaluate the function of the Ta-coated bone plate, animal experiments were conducted using a coat tibia fracture model. Our results showed that the Ta-coated bone plate could effectively fix the fracture. Both imaging and histological analysis showed that the Ta-coated bone plate had prominent indirect binding of callus formation. Histological results showed that new bone grew at the interface and formed good osseointegration with the host bone. Therefore, this study provides an alternative to bio-functional Ta-coated bone plates with improved osseointegration and osteogenic functions for orthopaedic applications.
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