Evidence map›Paper›PMID 34901523›Full record

ArticleClinical epidemiology and global health

Marburg virus disease outbreak amidst COVID-19 in the Republic of Guinea: A point of contention for the fragile health system?

Osaretin Christabel Okonji, Emeka Francis Okonji, Parvathy Mohanan, Maryam Salma Babar, Amna Saleem, Uzzam Ahmed Khawaja, Mohammad Yasir Essar, Mohammad Mehedi Hasan

Open access · goldAbstract read
In one paragraph

Article in Clinical epidemiology and global health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Refining early detection of Marburg Virus Disease (MVD) in Rwanda: Leveraging predictive symptom clusters to enhance case definitions.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025
    Article
  3. Article
  4. Antiviral Effect ofCurrent pharmaceutical biotechnology · 2025
    Review
  5. Article
  6. Article
  7. Can Marburg virus be sexually transmitted?Health science reports · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Rise of Marburg virus in Africa: a call for global preparedness.Annals of medicine and surgery (2012) · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 6 countries.

Osaretin Christabel OkonjiSchool of Pharmacy, University of the Western Cape, Bellville, South Africa.
Emeka Francis OkonjiSchool of Public Health, University of the Western Cape, Bellville, South Africa.
Parvathy MohananDepartment of General Medicine, Medical University of Sofia, Bulgaria.
Maryam Salma BabarDubai Medical College, Dubai, United Arab Emirates.
Amna SaleemJinnah Medical and Dental College, Karachi, Pakistan.
Uzzam Ahmed KhawajaJinnah Medical and Dental College, Karachi, Pakistan.
Mohammad Yasir EssarKabul University of Medical Sciences, Kabul, Afghanistan.
Mohammad Mehedi HasanDepartment of Biochemistry and Molecular Biology, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh.
Jinnah Medical & Dental College · PKUniversity of the Western Cape · ZADubai Medical College · AEKabul University · AFMawlana Bhashani Science and Technology University · BDMedical University of Sofia · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In August 2021, the Marburg virus disease (MVD) outbreak was confirmed amid the coronavirus disease 2019 (COVID-19) pandemic in the Republic of Guinea. This is the first time it is detected in Guinea and West Africa. Marburg virus is one of the world's most threatening diseases, causing severe haemorrhagic fever, with a case fatality rate of 90%. Currently, there are no vaccines and specific antiviral drugs for MVD. Technical teams and community health care workers that were set up as part of the recent Ebola virus disease (EVD) outbreak that was declared over on June 19, 2021, are now redeployed to support governments response activities of the MVD outbreak in the country. The MVD is an added burden to the fragile healthcare systems that are already overburdened with multiple reoccurring epidemics and the COVID-19 pandemic. Previous epidermic strategies are needed to contain the spread of the disease, amid the COVID-19 pandemic, so the health care systems are not overwhelmed. This commentary discusses the available evidence regarding the epidemic of MVD in Guinea amid the COVID-19 pandemic, and highlights the efforts, challenges to be prioritized, and provides evidence-based recommendations.

Indexed as

ALIMA, Alliance for Internal Medical ActionCFR, Case fatality rateCOVID-19COVID-19, Coronavirus disease 2019EVD, Ebola virus diseaseGuineaMarburg virus diseaseMVD, Marburg virus diseaseMV, Marburg virusPublic healthSARS-CoV-2, Severe acute respiratory syndrome coronavirus 2UNICEF, United Nations International Children's Emergency FundWest AfricaWHO, World Health Organization

Identifiers

PMID34901523
PMCPMC8651525
OpenAlexW4200416488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.