ArticleHeliyon2021
Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: An observational study.
Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Serum Copper Levels in Chronic Kidney Disease and Hemodialysis Patients: Insights from a Systematic Review and Meta-Analysis.Biological trace element research · 2025Pooled it
- Metal Homeostasis Imbalance as Potentially Contributing Mechanism in Onset of Cardiac Disorders in Individuals with Chronic Obstructive Pulmonary Disease and Chronic Kidney Disease.Biological trace element research · 2026Article
- Association Between Blood Lead Levels and Diabetic Kidney Disease: A Cross-sectional Analysis of NHANES Data (1999-2018).Current molecular medicine · 2026Article
- Environmental Exposure to Cadmium and Lead Exacerbates Kidney Function in People with Diabetes.Journal of xenobiotics · 2025Article
- Hemoglobin and mean platelet volume abnormalities in children exposed to heavy metals and metalloids in a pilot biomonitoring study.Scientific reports · 2025Article
- Association between copper exposure and renal fibrosis in patients with chronic kidney disease: evidence from Mendelian randomization and a retrospective study.Frontiers in public health · 2025Article
- Heavy metal association with chronic kidney disease of unknown cause in central India-results from a case-control study.BMC nephrology · 2024Article
- Comparative mathematical modeling of causal association between metal exposure and development of chronic kidney disease.Frontiers in endocrinology · 2024Article
- Occupational risks associated with chronic kidney disease of non-traditional origin (CKDnt) in Brazil: it is time to dig deeper into a neglected problem.Jornal brasileiro de nefrologia · 2024Article
- Urinary Levels of 14 Metal Elements in General Population: A Region-Based Exploratory Study in China.Toxics · 2023Article
- Interaction between Single Nucleotide Polymorphisms (SNP) of Tumor Necrosis Factor-Alpha (TNF-α) Gene and Plasma Arsenic and the Effect on Estimated Glomerular Filtration Rate (eGFR).International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The traditional causes of Chronic Kidney Damage (CKD) are Diabetes and Hypertension. However, recent studies reported the possible relations between metal exposure and CKD. This study aims to explore the status of metals in CKD patients compared to their healthy counterparts at Narayanganj, Bangladesh, through a cross-sectional study. In this study, 50 volunteers were involved; 30 CKD patients and 20 healthy controls. Five metals were measured from serum [Copper (Cu) and Zinc (Zn)] and urine [Lead (Pb), Cadmium (Cd), and Chromium (Cr)] using Atomic Absorption Spectrometry. Compared to the controls the CKD patients exhibited significantly higher levels of Pb, Cd and Cr levels in their urine samples. This signifies a potential association between heavy metal exposure and CKD. The serum levels of Cu were much higher than expected for CKD patients than controls, and the Zn values were in accordance with established literature. However, the level of Zn in blood was significantly lower in the CKD group compared to the control. This data suggests that the Cu imbalance in the serum of the CKD subjects might have been related to a myriad of reasons, the most plausible of which being exposed to large concentrations of the nephrotoxic metals such as Pb, Cd and Cr in this study. Our study has shed a much needed light on the correlation between CKD and exposure to heavy metals and imbalance of essential metals in blood serum, in a rural locality of Bangladesh.
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