ArticleFrontiers in cardiovascular medicine2021
Elucidation of a Causal Relationship Between Platelet Count and Hypertension: A Bi-Directional Mendelian Randomization Study.
Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Platelet indices and incident hypertension: effect modification by body mass index in a Chinese cohort.Journal of global health · 2026Article
- Systemic immune-inflammation Index and blood pressure control are independent and interactive predictors of atrial fibrillation recurrence after ablation.Frontiers in cardiovascular medicine · 2026Article
- PlateletBase: A Comprehensive Knowledgebase for Platelet Research and Disease Insights.Genomics, proteomics & bioinformatics · 2025Article
- Article
- The association of the platelet/high-density lipoprotein cholesterol ratio with self-reported stroke and cardiovascular mortality: a population-based observational study.Lipids in health and disease · 2024Observational
- Systemic immune-inflammation index predicts first stroke and affects the efficacy of folic acid in stroke prevention.Heliyon · 2024Article
- Gender differences in the relationship between the systemic immune-inflammation index and all-cause and cardiovascular mortality among adults with hypertension: evidence from NHANES 1999-2018.Frontiers in endocrinology · 2024Article
- Effects of Platelet Count on Blood Pressure: Evidence from Observational and Genetic Investigations.Genes · 2023Article
- Systemic inflammation markers and the prevalence of hypertension: A NHANES cross-sectional study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Platelet indices and blood pressure: a multivariable mendelian randomization study.Thrombosis journal · 2023Article
- Association of systemic immune inflammatory index with all-cause and cause-specific mortality in hypertensive individuals: Results from NHANES.Frontiers in immunology · 2023Article
- CALLY index and hypertension in diabetes: A composite inflammation-nutrition-immunity marker.Science progressArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension has been reported as a major risk factor for diseases such as cardiovascular disease, and associations between platelet activation and risk for hypertension are well-established. However, the exact nature of causality between them remains unclear. In this study, a bi-directional Mendelian randomization (MR) analysis was conducted on 15,996 healthy Taiwanese individuals aged between 30 and 70 years from the Taiwan Biobank, recorded between 2008 and 2015. The inverse variance weighted (IVW) method was applied to determine the causal relationship between platelet count and hypertension with single nucleotide polymorphisms as instrumental variables (IVs). Furthermore, to check for pleiotropy and validity of the IVs, sensitivity analyses were performed using the MR-Egger, weighted median and simple median methods. This study provided evidence in support of a positive causal effect of platelet count on the risk of hypertension (odds ratio: 1.149, 95% confidence interval: 1.131-1.578,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.