Evidence map›Paper›PMID 34901124›Full record

ArticleFrontiers in nutrition2021

Extracellular Vesicles Derived From

Stefania Paola Bruno, Alessandro Paolini, Valentina D'Oria, Angelo Sarra, Simona Sennato, Federico Bordi, Andrea Masotti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

  1. Pooled it
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  15. 80 years of extracellular vesicles: from discovery to clinical translation.Extracellular vesicles and circulating nucleic acids · 2026
    Review
  16. Frontiers in bioengineering and biotechnology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Stefania Paola BrunoResearch Laboratories, Children's Hospital Bambino Gesù-IRCCS, Rome, Italy.
Alessandro PaoliniResearch Laboratories, Children's Hospital Bambino Gesù-IRCCS, Rome, Italy.
Valentina D'OriaResearch Laboratories, Children's Hospital Bambino Gesù-IRCCS, Rome, Italy.
Angelo SarraMicroscopy Center, University of L'Aquila, L'Aquila, Italy.
Simona SennatoCNR-ISC UOS Sapienza and Department of Physics, Sapienza University of Rome, Rome, Italy.
Federico BordiCNR-ISC UOS Sapienza and Department of Physics, Sapienza University of Rome, Rome, Italy.
Andrea MasottiResearch Laboratories, Children's Hospital Bambino Gesù-IRCCS, Rome, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITSapienza University of Rome · ITUniversity of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is widely acknowledged that mammalian exosomes (or extracellular vesicles), have a key role in intercellular communication, owing to the presence of various bioactive molecules such as lipids, proteins, and microRNAs within their inner compartment. Most recently, the discovery of extracellular vesicles isolated from edible plants (such as vegetables and fruits) and their similarity in terms of size and content with exosomes has opened new perspectives on possible intercellular communication and regulation of important biological processes in which these vesicles are involved. It is also well-known that a balanced diet rich of fruits and vegetables (i.e., the Mediterranean diet) can contribute to maintain a "healthy gut" by preserving the intestinal epithelial barrier integrity and avoid that inflammatory stimuli that can alter homeostasis. In our study, we optimized a method to isolate extracellular vesicles from the orange juice

Indexed as

Citrus sinensisfruit-derived extracellular vesiclesinflammatory stimulusintestinal epitheliumintestinal permeability

Identifiers

PMID34901124
PMCPMC8652296
OpenAlexW3215985961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.