Evidence map›Paper›PMID 34900992›Full record

ArticleFrontiers in cell and developmental biology2021

Long Non-coding RNAs LINC01679 as a Competitive Endogenous RNAs Inhibits the Development and Progression of Prostate Cancer via Regulating the miR-3150a-3p/SLC17A9 Axis.

Yuan-Yuan Mi, Chuan-Yu Sun, Li-Feng Zhang, Jun Wang, Hong-Bao Shao, Feng Qin, Guo-Wei Xia, Li-Jie Zhu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Yuan-Yuan MiDepartment of Urology, Affiliated Hospital of Jiangnan University, Wuxi, China.
Chuan-Yu SunDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Li-Feng ZhangDepartment of Urology, Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China.
Jun WangDepartment of Urology, Affiliated Hospital of Jiangnan University, Wuxi, China.
Hong-Bao ShaoDepartment of Urology, Affiliated Hospital of Jiangnan University, Wuxi, China.
Feng QinDepartment of Urology, Affiliated Hospital of Jiangnan University, Wuxi, China.
Guo-Wei XiaDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Li-Jie ZhuDepartment of Urology, Affiliated Hospital of Jiangnan University, Wuxi, China.
Jiangnan University · CNWuxi Fourth People's Hospital · CNFudan University · CNHuashan Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) have been indicated as the candidate factors to predict cancer prognosis. However, it is still unknown whether lncRNA combinations may be utilized for predicting overall survival (OS) of prostate cancer (PCa). The present work focused on selecting the potent OS-related lncRNA signature for PCa and studying its molecular mechanism to enhance the prognosis prediction accuracy. Differentially expressed lncRNAs (DElncRNAs) or differentially expressed genes (DEGs) were obtained based on TCGA database by R software "edgeR" package. lncRNAs or mRNAs significantly related to PCa were screened through univariate as well as multivariate Cox regression, for the construction of the risk model for prognosis prediction. Moreover, this constructed risk model was validated through ROC analysis, univariate regression, and Kaplan-Meier (KM) analysis. Additionally, we built a lncRNA-miRNA-mRNA ceRNA network through bioinformatics analysis. Colony formation, CCK-8, flow cytometry, scratch, and Transwell assays were performed based on PCa cells subjected to small interfering RNA (siRNA) targeting LINC01679/SLC17A9 and vector expressing LINC01679/SLC17A9 transfection. Thereafter, the ceRNA mechanism was clarified

Indexed as

ceRNALINC01679miR-3150a-3pprostate cancerSLC17A9

Identifiers

PMID34900992
PMCPMC8656699
OpenAlexW3216003588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.