Evidence map›Paper›PMID 34900945›Full record

ArticleFrontiers in chemistry2021

A Novel Conductive Antibacterial Nanocomposite Hydrogel Dressing for Healing of Severely Infected Wounds.

Lizhi Xiao, Fang Hui, Tenghui Tian, Ruyue Yan, Jingwei Xin, Xinyu Zhao, Yingnan Jiang, Zhe Zhang, Yulan Kuang, Na Li and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 42 citations in OpenAlex.

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  13. Progress in Antibacterial Hydrogel Dressing.Gels (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Lizhi XiaoJilin Ginseng Academy, Hospital of Affiliated Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Fang HuiJilin Ginseng Academy, Hospital of Affiliated Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Tenghui TianJilin Ginseng Academy, Hospital of Affiliated Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Ruyue YanJilin Ginseng Academy, Hospital of Affiliated Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Jingwei XinState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Chinese-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
Xinyu ZhaoJilin Ginseng Academy, Hospital of Affiliated Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Yingnan JiangJilin Ginseng Academy, Hospital of Affiliated Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Zhe ZhangJilin Ginseng Academy, Hospital of Affiliated Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Yulan KuangJilin Ginseng Academy, Hospital of Affiliated Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Na LiKey Laboratory of Songliao Aquatic Environment of Ministry of Education, Jilin Jianzhu University, Changchun, China.
Yu ZhaoJilin Ginseng Academy, Hospital of Affiliated Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Quan LinState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Chinese-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
Changchun University of Chinese Medicine · CNJilin University · CNJilin Jianzhu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound infections are serious medical complications that can endanger human health. Latest researches show that conductive composite materials may make endogenous/exogenous electrical stimulation more effective, guide/comb cell migration to the wound, and subsequently promote wound healing. To accelerate infected wound healing, a novel medical silver nanoparticle-doped conductive polymer-based hydrogel system (Ag NPs/CPH) dressing with good conductivity, biocompatibility, and mechanical and antibacterial properties was fabricated. For the hydrogel dressing, Ag NPs/CPH, polyvinyl alcohol (PVA), and gelatin were used as the host matrix materials, and phytic acid (PA) was used as the cross-linking agent to introduce conductive polyaniline into the matrix, with antibacterial Ag NPs loaded via impregnation. After a series of analyses, the material containing 5 wt% of PVA by concentration, 1.5 wt% gelatin, 600 μL of AN reactive volume, and 600 μL of PA reactive volume was chosen for Ag NPs/CPH preparation. XPS and FTIR analysis had been further used to characterize the composition of the prepared Ag NPs/CPH. The test on the swelling property showed that the hydrogels had abundant pores with good water absorption (≈140% within 12 h). They can be loaded and continuously release Ag NPs. Thus, the prepared Ag NPs/CPH showed excellent antibacterial property with increasing duration of immersion of Ag NPs. Additionally, to evaluate

Indexed as

Ag nanoparticlesbacteriostatic medical hydrogelconductivityinfected wound healingnew animal model

Identifiers

PMID34900945
PMCPMC8652251
OpenAlexW3217056049

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.