Evidence map›Paper›PMID 34900814›Full record

ArticleJournal of diabetes and metabolic disorders2021

Salivary microRNA-126 and 135a: a potentially non-invasive diagnostic biomarkers of type- 2 diabetes.

Yousef Khazaei Monfared, Mohammad-Reza Mirzaii-Dizgah, Elham Khodabandehloo, Mohamad Reza Sarookhani, Sima Hashemipour, Iraj Mirzaii-Dizgah

Open access · greenAbstract read
In one paragraph

Article in Journal of diabetes and metabolic disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Role of microRNAs in Diabetes-Associated Periodontitis: A Scoping Review.Journal of International Society of Preventive & Community Dentistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Yousef Khazaei MonfaredCellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.ORCID https://orcid.org/0000-0002-1171-8670
Mohammad-Reza Mirzaii-DizgahStudent Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-0587-0182
Elham KhodabandehlooB.Sc of Medical Laboratory sciences, Dezful University of Medical Sciences, Dezful, Iran.
Mohamad Reza SarookhaniCellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Sima HashemipourMetabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Iraj Mirzaii-DizgahDepartment of Physiology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran.ORCID 0000-0003-3488-6842
Qazvin University of Medical Sciences · IRAja University of Medical Sciences · IRDezful University of Medical Sciences · IRIran University of Medical Sciences · IRUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEmerging of miRNAs have illustrated the new mechanistic layer to regulate type 2 diabetes process and suggests a possible role of these RNAs in this defect. Thus, we designed this study to improve our understanding of salivary miRNA-126 and 135a expression utility as an easy of collection and non-invasive way in diabetic patients instead of blood sample.

methodsThis case-control study was done on T

resultsA correlation was observed between the level of HbA1c, glucose and lipid profiles (TG, TC, and LDL) in serum and whole stimulated saliva samples in T

conclusionsThe results of this case and control study showed that miR-135a and miR126 expression in saliva fluid as a reliable biomarkers and non-invasive approach in combination by change of lipid profiles, glucose and HbA1c may be used to monitor diabetic and non-diabetic patients, while further research is needed to investigate the relationship of these salivary miRNAs (miR135a, miR126) levels change on shifting the levels of clinical laboratory outcomes.

Indexed as

miR126miR135aT2DWhole stimulated saliva

Identifiers

PMID34900814
PMCPMC8630249
OpenAlexW3209586942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.