Evidence map›Paper›PMID 34900789›Full record

ArticleJournal of diabetes and metabolic disorders2021

Association of vitamin D receptor gene polymorphism with the occurrence of low bone density, osteopenia, and osteoporosis in patients with type 2 diabetes.

Maryam Ghodsi, Abbas Ali Keshtkar, Farideh Razi, Mahsa Mohammad Amoli, Ensieh Nasli-Esfahani, Fariba Zarrabi, Patricia Khashayar, Alireza Khajavi, Bagher Larijani, Mohamad Reza Mohajeri-Tehrani

Open access · bronzeAbstract read
In one paragraph

Article in Journal of diabetes and metabolic disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Maryam GhodsiDiabetes Research Center (DRC), Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-8940-3970
Abbas Ali KeshtkarDepartment of Health Sciences Education Development, School of Public Health (SPH), Tehran University of Medical Sciences (TUMS), Tehran, Iran.ORCID 0000-0002-7305-8639
Farideh RaziDiabetes Research Center (DRC), Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0003-2350-9574
Mahsa Mohammad AmoliMetabolic Disorders Research Center (MDRC), Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran.ORCID 0000-0002-9168-9223
Ensieh Nasli-EsfahaniDiabetes Research Center (DRC), Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-6334-5469
Fariba ZarrabiPresent Address: Thrombosis Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-7831-0565
Patricia KhashayarPresent Address: Center for Microsystem Technology, Imec and Ghent University, Zwijnaarde, Ghent, Belgium.ORCID 0000-0002-3084-4074
Alireza KhajaviStudent Research Committee, Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-5238-792X
Bagher LarijaniEndocrinology and Metabolism Research Center (EMRC), Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran.ORCID 0000-0001-5386-7597
Mohamad Reza Mohajeri-TehraniEndocrinology and Metabolism Research Center (EMRC), Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran.ORCID 0000-0001-9014-8452
Tehran University of Medical Sciences · IRGhent University · BEIslamic Azad University, Science and Research Branch · IRResearch Institute for Endocrine Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to analyze the association between VDR gene polymorphism and the occurrence of "low bone density (LBD)/osteopenia/osteoporosis" or LBDOO in type 2 diabetes (T2D) patients among a clustered population in northwest of Iran. The studied VDR gene polymorphism included

methodsIn this population-based cross-sectional study, patients with T2D were identified within a group of 1266 participants based on self-report of diabetes, history of diabetes medication, and recorded laboratory data. Separately for each polymorphism and gender, crude and adjusted (age, BMI) odds ratios (ORs) were calculated for participants with T2D through logistic regression analysis.

resultsThe prevalence of T2D was 16.41% in people residing in the city of Sanandaj in 2011. Of the participants with T2D, 13.92% and 81.29% had osteoporosis and vitamin D deficiency, respectively. In women, the

conclusionThe polymorphism of both

Indexed as

Cluster random samplingEffect sizeLogistic regressionOsteoporosisType 2 diabetesVDR polymorphism

Identifiers

PMID34900789
PMCPMC8630208
OpenAlexW3017059389

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.