Evidence map›Paper›PMID 34900687›Full record

ArticleFrontiers in oncology2021

Hua Yu, Ying Bai, Jing Qiu, Xiaomei He, Junzhi Xiong, Qian Dai, Xingmin Wang, Yuanyuan Li, Halei Sheng, Rong Xin and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. mTOR Signaling in Macrophages: All Depends on the Context.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Review
  7. Prenylated Dihydroflavonol fromMolecules (Basel, Switzerland) · 2024
    Article
  8. Review
  9. Pathogens and global health · 2023
    Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Hua YuClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Ying BaiHealth Management Center, First Affiliated Hospital, Army Medical University, Chongqing, China.
Jing QiuClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Xiaomei HeClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Junzhi XiongClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Qian DaiClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Xingmin WangClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Yuanyuan LiClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Halei ShengClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Rong XinClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Lu JiangClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Qiaoqiao LiClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Defeng LiClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Hong ZhangAdministration Department of Nosocomial Infection, Xinqiao Hospital, Army Medical University, Chongqing, China.
Le ZhangClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Qian ChenClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Jin PengClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Xiaomei HuDepartment of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing, China.
Kebin ZhangClinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Army Medical University · CNXinqiao Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs), which display a tumor-supportive M2 phenotype, are closely related to tumor growth and metastasis. The reprogramming of TAMs toward a tumoricidal M1 profile has emerged as an attractive strategy for cancer immunotherapy. In this study, we found that the intratumoral injection of PcrV protein, a component of the

Indexed as

PcrV–TLR4 interactionPseudomonas aeruginosa PcrV proteinTAM reeducationTLR4/PI3K/AKT/mTOR-glycolysis-NO feedback looptumoricidal efficacy

Identifiers

PMID34900687
PMCPMC8654729
OpenAlexW3217621997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.