Evidence map›Paper›PMID 34900540›Full record

ArticleActa pharmaceutica Sinica. B2021

A smart O

Xiaojuan Zhang, Chuanchuan He, Yun Sun, Xiaoguang Liu, Yan Chen, Chen Chen, Ruicong Yan, Ting Fan, Tan Yang, Yao Lu and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 34 citations in OpenAlex.

  1. Charge-convertible MnOiScience · 2026
    Article
  2. Review
  3. Review
  4. CeOAsian journal of pharmaceutical sciences · 2025
    Article
  5. Article
  6. Nanotheranostics: A Cutting-edge Technology for Cancer Management.Current pharmaceutical biotechnology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Xiaojuan ZhangSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Chuanchuan HeSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yun SunInstitute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830011, China.
Xiaoguang LiuSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yan ChenSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Chen ChenSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Ruicong YanSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Ting FanSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Tan YangSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yao LuSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Jun LuoSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Xiang MaSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Guangya XiangSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Huazhong University of Science and Technology · CNXinjiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug transportation is impeded by various barriers in the hypoxic solid tumor, resulting in compromised anticancer efficacy. Herein, a solid lipid monostearin (MS)-coated CaO

Indexed as

CaO2ChemotherapyCTGF, connective tissue growth factorDOX, doxorubicinDSPE-PEG2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]ECM, extracellular matrixEPR, enhanced permeability and retentionFBS, fetal bovine serumHAase, hyaluronidaseHA, hyaluronic acidHIF-1HIF-1α, hypoxia-inducible factor 1αHypoxiaMCTS, multicellular tumor spheroidsMnO2MS, monostearinMTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideNanoparticleNP, nanoparticleOA, oleic acidPDT, photodynamic therapyP-gp, P-glycoproteinTEM, transmission electron microscopyTME, tumor microenvironmentTransportationTumor

Identifiers

PMID34900540
PMCPMC8642619
OpenAlexW3174291187

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.