Evidence map›Paper›PMID 34900485›Full record

ArticleCureus2021

Association of Serotonergic Pathway Gene Polymorphisms With Behavioral Parameters in Patients With Opioid Dependence.

Siddharth Sarkar, Renu Singh, Arundhati Sharma, Muzaffar A Pandit, Ranjan Gupta, Deepika Singhal, Raka Jain, Yatan P Balhara

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Siddharth SarkarNational Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, IND.
Renu SinghDepartment of Anatomy, All India Institute of Medical Sciences, New Delhi, IND.
Arundhati SharmaDepartment of Anatomy, All India Institute of Medical Sciences, New Delhi, IND.
Muzaffar A PanditNational Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, IND.
Ranjan GuptaDepartment of Anatomy, All India Institute of Medical Sciences, New Delhi, IND.
Deepika SinghalDepartment of Anatomy, All India Institute of Medical Sciences, New Delhi, IND.
Raka JainNational Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, IND.
Yatan P BalharaNational Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, IND.
All India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims Opioid dependence is a chronic, relapsing substance use disorder with a multifactorial etiology, including a genetic component. Serotonin pathway gene polymorphisms have been an important focus of research for psychiatric disorders, including substance use disorders. This study aimed to identify the association of serotonin pathway gene polymorphisms with self-harm, depressive symptoms, impulsiveness, and aggression in patients with opioid dependence. Method The study group comprised 366 subjects with opioid dependence and 200 healthy volunteers. Patients were assessed for a history of self-harm, depressive symptoms, impulsiveness, and aggression using standard tools. Genomic DNA was used for genotyping of four polymorphisms - 5-HTTLPR, STin2 VNTR,

Indexed as

impulsivenessopioid dependencepcrpolymorphismserotonin

Identifiers

PMID34900485
PMCPMC8647861
OpenAlexW3213161116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.